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Safety of a formulation containing chitosan microparticles with chamomile: blind controlled clinical trial

التفاصيل البيبلوغرافية
العنوان: Safety of a formulation containing chitosan microparticles with chamomile: blind controlled clinical trial
المؤلفون: Danielle Cristina Garbuio, Cristina Mara Zamarioli, Maísa Oliveira de Melo, Patrícia Maria Berardo Gonçalves Maia Campos, Emília Campos de Carvalho, Luis Alexandre Pedro de Freitas
المصدر: Revista Latino-Americana de Enfermagem, Vol 26, Iss 0 (2018)
بيانات النشر: Universidade de São Paulo, 2018.
سنة النشر: 2018
المجموعة: LCC:Nursing
مصطلحات موضوعية: Matricaria, Fármacos Dermatológicos, Prevenção e Controle, Enfermagem, Ensaio Clínico, Plantas Medicinais, Nursing, RT1-120
الوصف: ABSTRACT Objective: to evaluate the safety of a topical formulation containing chamomile microparticles coated with chitosan in the skin of healthy participants. Method: phase I blind, controlled, non-randomized, single-dose clinical trial with control for skin, base formulation, and formulation with microparticles. The variables analyzed were irritation and hydration by the Wilcoxon and Kruskall-Wallis tests. Results: the study started with 35 participants with a mean age of 26.3 years. Of these, 30 (85.71%) were female, 29 (82.90%) were white skinned and 32 (91.40%) had no previous pathologies. One participant was removed from the study reporting erythema at the site of application, and four other participants for not attending the last evaluation. In the 30 participants who completed the study, the tested formulation did not cause erythema, peeling, burning, pruritus or pain; there was an improvement in cutaneous hydration in the site of application of the formulation with microparticles. In the evaluation of the barrier function, there was an increase in transepidermal water loss in all sites. Conclusion: the formulation with chamomile microparticles is safe for topical use, not causing irritation and improving skin hydration over four weeks of use. Its effects on barrier function need further investigation. No. RBR-3h78kz in the Brazilian Registry of Clinical Trials (ReBEC).
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
Spanish; Castilian
Portuguese
تدمد: 1518-8345
Relation: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-11692018000100389&lng=en&tlng=en; https://doaj.org/toc/1518-8345
DOI: 10.1590/1518-8345.2648.3075
URL الوصول: https://doaj.org/article/f03a2bffc6ed42288a173150739d3b39
رقم الأكسشن: edsdoj.f03a2bffc6ed42288a173150739d3b39
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:15188345
DOI:10.1590/1518-8345.2648.3075