دورية أكاديمية
Effects of liraglutide on ANP secretion and cardiac dynamics
| العنوان: | Effects of liraglutide on ANP secretion and cardiac dynamics |
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| المؤلفون: | Shenghe Luo, Yunhui Zuo, Xiaotian Cui, Meiping Zhang, Honghua Jin, Lan Hong |
| المصدر: | Endocrine Connections, Vol 12, Iss 11, Pp 1-11 (2023) |
| بيانات النشر: | Bioscientifica, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Diseases of the endocrine glands. Clinical endocrinology |
| مصطلحات موضوعية: | liraglutide, glucagon-like peptide 1 (glp-1), atrial natriuretic peptide (anp), pi3k/akt/mtor, piezo 1, cathepsin k, atrial dynamics, Diseases of the endocrine glands. Clinical endocrinology, RC648-665 |
| الوصف: | To observe the effects of liraglutide (analog of glucagon-like peptide 1 (GLP-1)) on atrial natriuretic peptide (ANP) secretion and atrial dynamics, an ex vivo isolated rat atrial perfusion model was used to determine atrial ANP secretion and pulse pressure. DPP-4−/− mice were also established in vivo. ANP levels were determined by radioimmunoassay; GLP-1 content was determined by Elisa. The expression levels of GLP-1 receptor (GLP-1R), PI3K/AKT/mTOR, piezo 1, and cathepsin K were analyzed by Western blot. In the clinical study, patients with acute coronary syndrome (ACS) had low levels of plasma GLP-1 but relatively high levels of plasma ANP. In ex vivo (3.2 nmol/L) and in vivo (30 μg/kg) models, liraglutide significantly decreased ANP levels and atrial pulse pressure. Exendin9–39 alone (GLP-1R antagonist) reversibly significantly increased ANP secretion, and the reduction effect of liraglutide on the secret ion of ANP was significantly alleviated by Exendin9–39. Exendin9–39 demonstrated slightly decreased atrial pulse pressure; however, combined liraglutide and Exendin9–39 significantly decreased atrial pulse pressure. Ly294002 (PI3K/AKT inhibitor) inhibited the increase of ANP secretion by liraglutide for a short time, while Ly294002 didn't counteract the decrease in pulse pressure by liraglutide in atrial dynamics studies. Liraglutide increased the expression of GLP-1R and PI3K/AKT/mTOR in isolated rat atria and the hearts of mice in vivo, whereas Exendin9–39 reversibly reduced the expression of GLP-1R and PI3K/AKT/mTOR. Piezo 1 was significantly decreased in wild type and DPP-4−/− mouse heart or isolated rat atria after being treated with liraglutide. Cathepsin K expression was only decreased in in vivo model hearts. Liraglutide can inhibit ANP secretion while decreasing atrial pulse pressure mediated by GLP-1R. Liraglutide probably plays a role in the reduction of ANP secretion via the PI3K/AKT/mTOR signaling pathway. Piezo 1 and cathepsin K may be involved in the liraglutide mechanism of reduction. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2049-3614 14418460 |
| Relation: | https://ec.bioscientifica.com/view/journals/ec/12/11/EC-23-0176.xml; https://doaj.org/toc/2049-3614 |
| DOI: | 10.1530/EC-23-0176 |
| URL الوصول: | https://doaj.org/article/dcaf06a14418460aacf41e1da0bf6698 |
| رقم الأكسشن: | edsdoj.f06a14418460aacf41e1da0bf6698 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20493614 14418460 |
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| DOI: | 10.1530/EC-23-0176 |