دورية أكاديمية
Infiltration of T Cells into a Three-Dimensional Psoriatic Skin Model Mimics Pathological Key Features
| العنوان: | Infiltration of T Cells into a Three-Dimensional Psoriatic Skin Model Mimics Pathological Key Features |
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| المؤلفون: | Isabelle Lorthois, Mélissa Simard, Sophie Morin, Roxane Pouliot |
| المصدر: | International Journal of Molecular Sciences, Vol 20, Iss 7, p 1670 (2019) |
| بيانات النشر: | MDPI AG, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | psoriasis, T cells, adaptive immunity, inflammation, 3D model, tissue engineering, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | Psoriasis is an autoimmune chronic dermatosis that is T cell-mediated, characterized by epidermal thickening, aberrant epidermal differentiation and inflammatory infiltrates, with a dominant Th1 and Th17 profile. Additional in vitro models are required to study the complex interactions between activated T cells and skin cells, and to develop new, more effective treatments. We have therefore sought to model this psoriatic inflammation by the generation of tissue-engineered immunocompetent tissues, and we have investigated the response of activated T-cell infiltration in models produced with lesional psoriatic skin cells on major hallmarks of psoriasis. The immunocompetent lesional skin model displayed a delayed onset of epidermal differentiation, an hyperproliferation of the basal keratinocytes, a drastic increase in the secretion of proinflammatory cytokines, and a disturbed expression of key transcription factors, as observed in lesional plaques, suggesting a crucial importance of combining the pathological phenotype of cutaneous cells to T cells in order to generate a relevant model for psoriasis. Finally, we found this skin model to be responsive to methotrexate treatment, making it a valuable tool for drug development. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 |
| Relation: | https://www.mdpi.com/1422-0067/20/7/1670; https://doaj.org/toc/1422-0067 |
| DOI: | 10.3390/ijms20071670 |
| URL الوصول: | https://doaj.org/article/f07c7349583946208ba0a04e2201d657 |
| رقم الأكسشن: | edsdoj.f07c7349583946208ba0a04e2201d657 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 |
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| DOI: | 10.3390/ijms20071670 |