دورية أكاديمية
IKKε isoform switching governs the immune response against EV71 infection
العنوان: | IKKε isoform switching governs the immune response against EV71 infection |
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المؤلفون: | Ya-Ling Chang, Yu-Wen Liao, Min-Hsuan Chen, Sui-Yuan Chang, Yao-Ting Huang, Bing-Ching Ho, Sung-Liang Yu |
المصدر: | Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021) |
بيانات النشر: | Nature Portfolio, 2021. |
سنة النشر: | 2021 |
المجموعة: | LCC:Biology (General) |
مصطلحات موضوعية: | Biology (General), QH301-705.5 |
الوصف: | Chang et al. show that Enterovirus 71 (EV71) infection upregulates IKKε isoform 2 (IKKε v2), which in turn activates interferon regulatory factor 7 (IRF7). This study suggests that host cells trigger IKKε isoform switching to increase the production of interferon against EV71 infection, providing a potential strategy for boosting host’s antiviral defense. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 2399-3642 10564527 |
Relation: | https://doaj.org/toc/2399-3642 |
DOI: | 10.1038/s42003-021-02187-x |
URL الوصول: | https://doaj.org/article/cf0a06bd1056452785cc2fdda4a477a3 |
رقم الأكسشن: | edsdoj.f0a06bd1056452785cc2fdda4a477a3 |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 23993642 10564527 |
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DOI: | 10.1038/s42003-021-02187-x |