دورية أكاديمية
Monitoring Anti-PEG Antibodies Level upon Repeated Lipid Nanoparticle-Based COVID-19 Vaccine Administration
| العنوان: | Monitoring Anti-PEG Antibodies Level upon Repeated Lipid Nanoparticle-Based COVID-19 Vaccine Administration |
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| المؤلفون: | Giuditta Guerrini, Sabrina Gioria, Aisha V. Sauer, Simone Lucchesi, Francesca Montagnani, Gabiria Pastore, Annalisa Ciabattini, Donata Medaglini, Luigi Calzolai |
| المصدر: | International Journal of Molecular Sciences, Vol 23, Iss 16, p 8838 (2022) |
| بيانات النشر: | MDPI AG, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | lipid-nanoparticle-mRNA (LNP-mRNA)-based vaccine, anti-PEG Ig, COVID-19, anti-Spike Ig, SARS-CoV-2, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | PEGylated lipids are one of the four constituents of lipid nanoparticle mRNA COVID-19 vaccines. Therefore, various concerns have been raised on the generation of anti-PEG antibodies and their potential role in inducing hypersensitivity reactions following vaccination or in reducing vaccine efficacy due to anti-carrier immunity. Here, we assess the prevalence of anti-PEG antibodies, in a cohort of vaccinated individuals, and give an overview of their time evolution after repeated vaccine administrations. Results indicate that, in our cohort, the presence of PEG in the formulation did not influence the level of anti-Spike antibodies generated upon vaccination and was not related to any reported, serious adverse effects. The time-course analysis of anti-PEG IgG showed no significant booster effect after each dose, whereas for IgM a significant increase in antibody levels was detected after the first and third dose. Data suggest that the presence of PEG in the formulation does not affect safety or efficacy of lipid-nanoparticle-based COVID-19 vaccines. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 23168838 1422-0067 1661-6596 |
| Relation: | https://www.mdpi.com/1422-0067/23/16/8838; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067 |
| DOI: | 10.3390/ijms23168838 |
| URL الوصول: | https://doaj.org/article/df0f9c641e144575bc452b6e0ba1cb2c |
| رقم الأكسشن: | edsdoj.f0f9c641e144575bc452b6e0ba1cb2c |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 23168838 14220067 16616596 |
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| DOI: | 10.3390/ijms23168838 |