دورية أكاديمية
Correlation between aluminum concentration and miR-134-3p expression in peripheral blood in occupational aluminum exposed workers
| العنوان: | Correlation between aluminum concentration and miR-134-3p expression in peripheral blood in occupational aluminum exposed workers |
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| المؤلفون: | Jiarui HAO, Wenjing LI, Chunman YUAN, Xiaoting LU, Linping WANG, Qiao NIU, Jing SONG |
| المصدر: | 环境与职业医学, Vol 40, Iss 5, Pp 545-550 (2023) |
| بيانات النشر: | Editorial Committee of Journal of Environmental and Occupational Medicine, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Medicine (General) LCC:Toxicology. Poisons |
| مصطلحات موضوعية: | aluminum, blood aluminum, mir-134-3p, generalized linear model, Medicine (General), R5-920, Toxicology. Poisons, RA1190-1270 |
| الوصف: | BackgroundPrevious studies show that aluminum exposure could increase the expression of miRNA-134-3p, which is involved in the mechanism of aluminum induced learning and memory impairment. However, it has not been investigated whether the expression level of miRNA-134-3p in the peripheral blood of occupational aluminum exposed workers is related to the blood aluminum concentration yet.ObjectiveTo evaluate a potential correlation between aluminum concentration in peripheral blood and miR-134-3p expression in occupational aluminum exposed workers.MethodsA total of 184 male aluminum workers in the electrolytic aluminum workshop, aluminum oxide workshop, and thermal power workshop of an aluminum plant in Shanxi were selected by cluster sampling. They were divided into four groups (Q1-Q4) according to the quartiles of blood aluminum concentration, with 46 workers in each group. The basic information of workers was collected by questionnaire survey, and the cognitive function of workers was evaluated by Montreal Cognitive Assessment (MoCA). The plasma of workers was collected, and the relative expression level of miR-134-3p in plasma was detected by real-time quantitative polymerase chain reaction (RT-PCR). The plasma aluminum concentration was detected by inductively coupled plasma mass spectrometry (ICP-MS). The associations among workers' peripheral blood aluminum concentration, plasma miR-134-3p expression level, and total MoCA score were evaluated by generalized linear models.ResultsThe workers' medians (P25, P75) of blood aluminum concentration, plasma relative expression level of miR-134-3p, and MoCA score were 39.31 (25.30, 57.41) μg·L-1, 2.93 (2.29, 3.74), and 22.0 (20.0, 26.0), respectively. The results of the generalized linear model showed that after adjusting for age, body mass index, smoking, and alcohol consumption, compared with the Q1 group, blood aluminum in the Q2, Q3, or Q4 group had an impact on related plasma miR-134-3p expression level and total MoCA score (P0, Ptrend0.05).ConclusionOccupational aluminum exposure can lead to an increase in the expression level of miR-134-3p in plasma of workers, which may be related to a decrease in cognitive function of workers. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English Chinese |
| تدمد: | 2095-9982 |
| Relation: | http://www.jeom.org/article/cn/10.11836/JEOM22449; https://doaj.org/toc/2095-9982 |
| DOI: | 10.11836/JEOM22449 |
| URL الوصول: | https://doaj.org/article/f1084cff7c8a4693a1827e589549dbd8 |
| رقم الأكسشن: | edsdoj.f1084cff7c8a4693a1827e589549dbd8 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20959982 |
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| DOI: | 10.11836/JEOM22449 |