دورية أكاديمية
أعرض في EDS

Association between Polymorphisms in Cancer-Related Genes and Early Onset of Esophageal Adenocarcinoma

التفاصيل البيبلوغرافية
العنوان: Association between Polymorphisms in Cancer-Related Genes and Early Onset of Esophageal Adenocarcinoma
المؤلفون: I-Chen Wu, Yang Zhao, Rihong Zhai, Geoffrey Liu, Monica Ter-Minassian, Kofi Asomaning, Li Su, Chen-yu Liu, Feng Chen, Matthew H. Kulke, Rebecca S. Heist, David C. Christiani
المصدر: Neoplasia: An International Journal for Oncology Research, Vol 13, Iss 4, Pp 386-392 (2011)
بيانات النشر: Elsevier, 2011.
سنة النشر: 2011
المجموعة: LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
مصطلحات موضوعية: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
الوصف: There is an increasing incidence of esophageal adenocarcinoma (EA) among younger people in the western populations. However, the association between genetic polymorphisms and the age of EA onset is unclear. In this study, 1330 functional/tagging single-nucleotide polymorphisms (SNPs) from 354 cancer-related genes were genotyped in 335 white EA patients. Twenty important SNPs that have the highest importance scores and lowest classification error rate were identified by the random forest algorithm to be associated with early onset of EA (age ≤ 55 years). Subsequent logistic regression analysis indicated that 10 SNPs (rs2070744 of NOS3, rs720321 of BCL2, rs17757541 of BCL2, rs11775256 of TNFRSF10A, rs1035142 of CASP8, rs2236302 of MMP14, rs4740363 of ABL1, rs696217 of GHRL, rs2445762 of CYP19A1, and rs11941492 of VEGFR2/KDR) were significantly associated with early onset of EA (≤55 vs >55 years, all P < .05 after adjusting for co-variates and false discovery rate). Among them, five SNPs in the NOS3, BCL2, TNFRSF10A, and CASP8 genes were known to be involved in apoptosis processes. In Kaplan-Meier analyses, rs2070744 of NOS3, rs720321 of BCL2, and rs1035142 of CASP8 were also significantly associated with early onset of EA. Moreover, there was a higher risk of developing EA at a younger age when one had more risk genotypes. In conclusion, polymorphisms in cancer-related genes, especially those in the apoptotic pathway, play an important role in the development of younger-aged EA in a dose-response manner.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1476-5586
1522-8002
Relation: http://www.sciencedirect.com/science/article/pii/S1476558611800205; https://doaj.org/toc/1476-5586; https://doaj.org/toc/1522-8002
DOI: 10.1593/neo.101722
URL الوصول: https://doaj.org/article/f12962f3b9594be7a049923549332727
رقم الأكسشن: edsdoj.f12962f3b9594be7a049923549332727
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:14765586
15228002
DOI:10.1593/neo.101722