دورية أكاديمية
Evaluation of the Association Metformin: Plantago ovata Husk in Diabetic Rabbits
| العنوان: | Evaluation of the Association Metformin: Plantago ovata Husk in Diabetic Rabbits |
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| المؤلفون: | Raquel Díez-Láiz, Juan J. García-Vieitez, M. José Diez-Liébana, Matilde Sierra-Vega, Ana M. Sahagún-Prieto, Ángela P. Calle-Pardo, Nélida Fernández-Martínez |
| المصدر: | Journal of Diabetes Research, Vol 2015 (2015) |
| بيانات النشر: | Hindawi Limited, 2015. |
| سنة النشر: | 2015 |
| المجموعة: | LCC:Diseases of the endocrine glands. Clinical endocrinology |
| مصطلحات موضوعية: | Diseases of the endocrine glands. Clinical endocrinology, RC648-665 |
| الوصف: | In this experimental study we have investigated whether the inclusion of the dietary fiber Plantago ovata husk could be recommended as coadjuvant in treatments with oral hypoglycemic drugs. We evaluated the use of Plantago ovata husk-metformin association in diabetic rabbits by determining its effects on glucose and insulin concentrations. Six groups of 6 rabbits were used. Groups 1 to 3 were fed with standard chow and groups 4 to 6 with chow supplemented with Plantago ovata husk (3.5 mg/kg/day). Two groups (numbers 1 and 4) were used as controls (receiving standard or supplemented chow), two groups (numbers 2 and 5) received metformin orally, and the other two (numbers 3 and 6) were treated orally with metformin and psyllium. Plasma glucose concentrations were lower in groups fed with fiber-supplemented chow whereas insulin levels showed important interindividual variations. Glucose pharmacokinetics parameters showed significant differences in Cmax and tmax in relation to fiber intake. Insulin pharmacokinetics parameters after treatment with oral metformin showed an important increase in Cmax, AUC, and tmax in animals fed with fiber. We conclude that Plantago ovata husk intake can contribute to the oral antihyperglycemic treatment of type 2 diabetes. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2314-6745 2314-6753 |
| Relation: | https://doaj.org/toc/2314-6745; https://doaj.org/toc/2314-6753 |
| DOI: | 10.1155/2015/167526 |
| URL الوصول: | https://doaj.org/article/f17c06fd900f402e8ff6182e7c1a594a |
| رقم الأكسشن: | edsdoj.f17c06fd900f402e8ff6182e7c1a594a |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 23146745 23146753 |
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| DOI: | 10.1155/2015/167526 |