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A cross-sectional case–control study on the structural connectome in recovered hospitalized COVID-19 patients

التفاصيل البيبلوغرافية
العنوان: A cross-sectional case–control study on the structural connectome in recovered hospitalized COVID-19 patients
المؤلفون: Elke Lathouwers, Ahmed Radwan, Jeroen Blommaert, Lara Stas, Bruno Tassignon, Sabine D. Allard, Filip De Ridder, Elisabeth De Waele, Nicole Hoornaert, Patrick Lacor, Rembert Mertens, Maarten Naeyaert, Hubert Raeymaekers, Lucie Seyler, Anne-Marie Vanbinst, Lien Van Liedekerke, Jeroen Van Schependom, Peter Van Schuerbeek, Steven Provyn, Bart Roelands, Marie Vandekerckhove, Romain Meeusen, Stefan Sunaert, Guy Nagels, Johan De Mey, Kevin De Pauw
المصدر: Scientific Reports, Vol 13, Iss 1, Pp 1-17 (2023)
بيانات النشر: Nature Portfolio, 2023.
سنة النشر: 2023
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: Abstract COVID-19 can induce neurological sequelae, negatively affecting the quality of life. Unravelling this illness's impact on structural brain connectivity, white-matter microstructure (WMM), and cognitive performance may help elucidate its implications. This cross-sectional study aimed to investigate differences in these factors between former hospitalised COVID-19 patients (COV) and healthy controls. Group differences in structural brain connectivity were explored using Welch-two sample t-tests and two-sample Mann–Whitney U tests. Multivariate linear models were constructed (one per region) to examine fixel-based group differences. Differences in cognitive performance between groups were investigated using Wilcoxon Rank Sum tests. Possible effects of bundle-specific FD measures on cognitive performance were explored using a two-group path model. No differences in whole-brain structural organisation were found. Bundle-specific metrics showed reduced fiber density (p = 0.012, Hedges’ g = 0.884) and fiber density cross-section (p = 0.007, Hedges’ g = 0.945) in the motor segment of the corpus callosum in COV compared to healthy controls. Cognitive performance on the motor praxis and digit symbol substitution tests was worse in COV than healthy controls (p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2045-2322
Relation: https://doaj.org/toc/2045-2322
DOI: 10.1038/s41598-023-42429-y
URL الوصول: https://doaj.org/article/f23de6c0e8044b008932f517f27292d5
رقم الأكسشن: edsdoj.f23de6c0e8044b008932f517f27292d5
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20452322
DOI:10.1038/s41598-023-42429-y