دورية أكاديمية
A recurrent, fatal, DRESS syndrome, complicated by sepsis and severe systemic cytomegalovirus reactivation at relapse: a case report
| العنوان: | A recurrent, fatal, DRESS syndrome, complicated by sepsis and severe systemic cytomegalovirus reactivation at relapse: a case report |
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| المؤلفون: | Anna Castrovilli, Tommaso Mastrofilippo, Lucia Di Fino, Caterina Foti, Giuseppe Ingravallo, Antonio Perrone, Carlo Sabbà, Francesco Saverio Vella |
| المصدر: | Italian Journal of Medicine, Vol 12 (2018) |
| بيانات النشر: | PAGEPress Publications, 2018. |
| سنة النشر: | 2018 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | DRESS syndrome, allopurinol, Herpes viruses, sepsis, antivirals., Medicine |
| الوصف: | We report a case of recurrent, fatal, DRESS (drug reaction with eosinophilia and systemic symptoms) syndrome induced by allopurinol. A 57-year-old man was admitted to our clinic manifesting a severe skin rash and fever, after following a four-week-long allopurinol therapy. On the basis of clinical, laboratory and instrumental features, the patient was diagnosed with DRESS syndrome, following RegiSCAR and Japanese group’s criteria. The clinical course of the disease was complicated by viral infection, methicillin-resistant Staphylococcus aureus endocarditis, bacterial pneumonia and severe recurrences. Despite allopurinol therapy was suspended and systemic steroids, targeted antibiotics, ganciclovir and immunoglobulins were administered, the clinical course had a fatal outcome. Herpes viruses have shown to have a crucial role in the pathogenesis of severe DRESS syndrome, suggesting that an early use of antiviral therapy, in addition to steroids, could improve the prognosis of DRESS syndrome. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1877-9344 1877-9352 |
| Relation: | https://www.italjmed.org/index.php/ijm/article/view/1091; https://doaj.org/toc/1877-9344; https://doaj.org/toc/1877-9352 |
| DOI: | 10.4081/itjm.2018.1091 |
| URL الوصول: | https://doaj.org/article/f2415ceb77674486ac2f37aa29452482 |
| رقم الأكسشن: | edsdoj.f2415ceb77674486ac2f37aa29452482 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 18779344 18779352 |
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| DOI: | 10.4081/itjm.2018.1091 |