دورية أكاديمية
An immunomodulating peptide to counteract solar radiation-induced immunosuppression and DNA damage
| العنوان: | An immunomodulating peptide to counteract solar radiation-induced immunosuppression and DNA damage |
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| المؤلفون: | Michael Agrez, Mark Stephen Rybchyn, Warusavithana Gunawardena Manori De Silva, Rebecca Sara Mason, Christopher Chandler, Terrence J. Piva, Kristofer Thurecht, Nicholas Fletcher, Feifei Liu, Gayathri Subramaniam, Christopher B. Howard, Benjamin Blyth, Stephen Parker, Darryl Turner, Justyna Rzepecka, Gavin Knox, Anastasia Nika, Andrew Hall, Hayley Gooding, Laura Gallagher |
| المصدر: | Scientific Reports, Vol 13, Iss 1, Pp 1-19 (2023) |
| بيانات النشر: | Nature Portfolio, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | Abstract Ultraviolet radiation (UVR) induces immunosuppression and DNA damage, both of which contribute to the rising global incidence of skin cancer including melanoma. Nucleotide excision repair, which is activated upon UVR-induced DNA damage, is linked to expression of interleukin-12 (IL-12) which serves to limit immunosuppression and augment the DNA repair process. Herein, we report an immunomodulating peptide, designated IK14800, that not only elicits secretion of IL-12, interleukin-2 (IL-2) and interferon-gamma (IFN-γ) but also reduces DNA damage in the skin following exposure to UVR. Combined with re-invigoration of exhausted CD4+ T cells, inhibition of UVR-induced MMP-1 release and suppression of B16F10 melanoma metastases, IK14800 offers an opportunity to gain further insight into mechanisms underlying the development and progression of skin cancers. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2045-2322 |
| Relation: | https://doaj.org/toc/2045-2322 |
| DOI: | 10.1038/s41598-023-38890-4 |
| URL الوصول: | https://doaj.org/article/f251f6ca5a284aecb13cf3fec110b151 |
| رقم الأكسشن: | edsdoj.f251f6ca5a284aecb13cf3fec110b151 |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 20452322 |
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| DOI: | 10.1038/s41598-023-38890-4 |