دورية أكاديمية
Retrospective cohort study on the safety and efficacy of docetaxel in Japanese non‐small cell lung cancer patients with nondialysis chronic kidney disease stage 3b or higher
| العنوان: | Retrospective cohort study on the safety and efficacy of docetaxel in Japanese non‐small cell lung cancer patients with nondialysis chronic kidney disease stage 3b or higher |
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| المؤلفون: | Satoshi Anai, Ritsu Ibusuki, Tomoaki Takao, Yuko Sakurai, Junko Hisasue, Yoichi Takaki, Naohiko Hara |
| المصدر: | Thoracic Cancer, Vol 10, Iss 12, Pp 2282-2288 (2019) |
| بيانات النشر: | Wiley, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | Chronic kidney disease, docetaxel, estimated glomerular filtration rate, non‐small‐cell lung cancer, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Abstract Background It has been reported that 20% of lung cancer patients have renal impairment caused by chronic kidney disease (CKD). Since docetaxel is predominantly excreted by the hepatobiliary system, it is administered to non‐small cell lung cancer (NSCLC) patients with renal impairment. However, few clinical data are available on the toxicity and efficacy of docetaxel for patients with nondialysis renal impairment. Furthermore, some cases of tubular nephrotoxicity caused by docetaxel in NSCLC patients have been reported. Therefore, a retrospective cohort study was conducted to assess the influence of nondialysis CKD on the toxicity and efficacy of docetaxel in NSCLC patients. Methods NSCLC patients who received docetaxel were assessed for renal function, occurrence of adverse events and treatment efficacy. Results A total of 34 NSCLC patients who received docetaxel were studied. Eight (23.5%) patients had nondialysis CKD stage 3b or higher, with an estimated glomerular filtration rate (eGFR) |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1759-7714 1759-7706 |
| Relation: | https://doaj.org/toc/1759-7706; https://doaj.org/toc/1759-7714 |
| DOI: | 10.1111/1759-7714.13222 |
| URL الوصول: | https://doaj.org/article/f26f4e5c62e04ffd895c409b30e44062 |
| رقم الأكسشن: | edsdoj.f26f4e5c62e04ffd895c409b30e44062 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 17597714 17597706 |
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| DOI: | 10.1111/1759-7714.13222 |