دورية أكاديمية
The Head and Neck Squamous Cell Carcinoma Microenvironment as a Potential Target for Cancer Therapy
| العنوان: | The Head and Neck Squamous Cell Carcinoma Microenvironment as a Potential Target for Cancer Therapy |
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| المؤلفون: | Jan Plzák, Jan Bouček, Veronika Bandúrová, Michal Kolář, Miluše Hradilová, Pavol Szabo, Lukáš Lacina, Martin Chovanec, Karel Smetana |
| المصدر: | Cancers, Vol 11, Iss 4, p 440 (2019) |
| بيانات النشر: | MDPI AG, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | cancer, cancer microenvironment, cancer ecosystem, cancer-associated fibroblast, extracellular matrix, cytokine, IL-6, tumour-associated macrophages, cancer therapy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Similarly to other types of malignant tumours, the incidence of head and neck cancer is increasing globally. It is frequently associated with smoking and alcohol abuse, and in a broader sense also with prolonged exposure to these factors during ageing. A higher incidence of tumours observed in younger populations without a history of alcohol and tobacco abuse may be due to HPV infection. Malignant tumours form an intricate ecosystem of cancer cells, fibroblasts, blood/lymphatic capillaries and infiltrating immune cells. This dynamic system, the tumour microenvironment, has a significant impact on the biological properties of cancer cells. The microenvironment participates in the control of local aggressiveness of cancer cells, their growth, and their consequent migration to lymph nodes and distant organs during metastatic spread. In cancers originating from squamous epithelium, a similarity was demonstrated between the cancer microenvironment and healing wounds. In this review, we focus on the specificity of the microenvironment of head and neck cancer with emphasis on the mechanism of intercellular crosstalk manipulation for potential therapeutic application. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2072-6694 11040440 |
| Relation: | https://www.mdpi.com/2072-6694/11/4/440; https://doaj.org/toc/2072-6694 |
| DOI: | 10.3390/cancers11040440 |
| URL الوصول: | https://doaj.org/article/f281d87d4c4047de8f5fd03bd37cba57 |
| رقم الأكسشن: | edsdoj.f281d87d4c4047de8f5fd03bd37cba57 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20726694 11040440 |
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| DOI: | 10.3390/cancers11040440 |