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Possible Approaches to Studying the Influence of Magnetic Fields and Mechanical Effects on the Physicochemical Properties of Aqueous IgG Colloids

التفاصيل البيبلوغرافية
العنوان: Possible Approaches to Studying the Influence of Magnetic Fields and Mechanical Effects on the Physicochemical Properties of Aqueous IgG Colloids
المؤلفون: Egor I. Nagaev, Elena A. Molkova, Vladimir I. Pustovoy, Tatyana A. Matveeva, Dmitry A. Zakharov, Alexander V. Simakin, Evgenia V. Stepanova, Natalia A. Semenova, Veronika E. Reut, Valery P. Kalinitchenko, Valery A. Kozlov, Nikolai F. Bunkin
المصدر: Applied Sciences, Vol 13, Iss 24, p 13055 (2023)
بيانات النشر: MDPI AG, 2023.
سنة النشر: 2023
المجموعة: LCC:Technology
LCC:Engineering (General). Civil engineering (General)
LCC:Biology (General)
LCC:Physics
LCC:Chemistry
مصطلحات موضوعية: water, protein colloids, immunoglobulin G, magnetic fields, mechanical influences, Technology, Engineering (General). Civil engineering (General), TA1-2040, Biology (General), QH301-705.5, Physics, QC1-999, Chemistry, QD1-999
الوصف: The influence of various mechanical influences (transfusion, stirring, vibration, shaking, etc.) and magnetic installations (used in the application of spin chemistry methods) on colloidal solutions of protein and water, which are often used in pharmaceutical production, was studied. It has been shown that when mechanical influences are applied, physical and chemical properties of water and aqueous colloids of the IgG protein are changed. Magnetic fields do not have a significant effect on water; however, variation in a number of physical and chemical characteristics is observed in protein colloids. Moreover, the effect after exposure to magnetic fields with a frequency of 8 Hz is higher compared to the effect after exposure to magnetic fields with a frequency of 50 Hz. This effect persists even at extremely low concentrations of IgG protein molecules. The measurement system proposed in this work makes it possible to monitor the state of protein molecules in a non-invasive mode. In the future, optical and potentiometric methods built into flow systems can be used at all stages of the production of protein pharmaceuticals.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2076-3417
Relation: https://www.mdpi.com/2076-3417/13/24/13055; https://doaj.org/toc/2076-3417
DOI: 10.3390/app132413055
URL الوصول: https://doaj.org/article/f2bc574b38a64951bac0908e6cf71127
رقم الأكسشن: edsdoj.f2bc574b38a64951bac0908e6cf71127
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20763417
DOI:10.3390/app132413055