دورية أكاديمية
Isolation of Mycobacterium avium subspecies paratuberculosis reactive CD4 T cells from intestinal biopsies of Crohn's disease patients.
العنوان: | Isolation of Mycobacterium avium subspecies paratuberculosis reactive CD4 T cells from intestinal biopsies of Crohn's disease patients. |
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المؤلفون: | Ingrid Olsen, Stig Tollefsen, Claus Aagaard, Liv J Reitan, John P Bannantine, Peter Andersen, Ludvig M Sollid, Knut E A Lundin |
المصدر: | PLoS ONE, Vol 4, Iss 5, p e5641 (2009) |
بيانات النشر: | Public Library of Science (PLoS), 2009. |
سنة النشر: | 2009 |
المجموعة: | LCC:Medicine LCC:Science |
مصطلحات موضوعية: | Medicine, Science |
الوصف: | BACKGROUND:Crohn's disease (CD) is a chronic granulomatous inflammation of the intestine. The etiology is unknown, but an excessive immune response to bacteria in genetically susceptible individuals is probably involved. The response is characterized by a strong Th1/Th17 response, but the relative importance of the various bacteria is not known. METHODOLOGY/PRINCIPAL FINDINGS:In an attempt to address this issue, we made T-cell lines from intestinal biopsies of patients with CD (n = 11), ulcerative colitis (UC) (n = 13) and controls (n = 10). The T-cell lines were tested for responses to various bacteria. A majority of the CD patients with active disease had a dominant response to Mycobacterium avium subspecies paratuberculosis (MAP). The T cells from CD patients also showed higher proliferation in response to MAP compared to UC patients (p |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 1932-6203 |
Relation: | http://europepmc.org/articles/PMC2682569?pdf=render; https://doaj.org/toc/1932-6203 |
DOI: | 10.1371/journal.pone.0005641 |
URL الوصول: | https://doaj.org/article/f2bf05443f4a41ee8058bed52932fb1d |
رقم الأكسشن: | edsdoj.f2bf05443f4a41ee8058bed52932fb1d |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 19326203 |
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DOI: | 10.1371/journal.pone.0005641 |