دورية أكاديمية
أعرض في EDS

Isolation of Mycobacterium avium subspecies paratuberculosis reactive CD4 T cells from intestinal biopsies of Crohn's disease patients.

التفاصيل البيبلوغرافية
العنوان: Isolation of Mycobacterium avium subspecies paratuberculosis reactive CD4 T cells from intestinal biopsies of Crohn's disease patients.
المؤلفون: Ingrid Olsen, Stig Tollefsen, Claus Aagaard, Liv J Reitan, John P Bannantine, Peter Andersen, Ludvig M Sollid, Knut E A Lundin
المصدر: PLoS ONE, Vol 4, Iss 5, p e5641 (2009)
بيانات النشر: Public Library of Science (PLoS), 2009.
سنة النشر: 2009
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: BACKGROUND:Crohn's disease (CD) is a chronic granulomatous inflammation of the intestine. The etiology is unknown, but an excessive immune response to bacteria in genetically susceptible individuals is probably involved. The response is characterized by a strong Th1/Th17 response, but the relative importance of the various bacteria is not known. METHODOLOGY/PRINCIPAL FINDINGS:In an attempt to address this issue, we made T-cell lines from intestinal biopsies of patients with CD (n = 11), ulcerative colitis (UC) (n = 13) and controls (n = 10). The T-cell lines were tested for responses to various bacteria. A majority of the CD patients with active disease had a dominant response to Mycobacterium avium subspecies paratuberculosis (MAP). The T cells from CD patients also showed higher proliferation in response to MAP compared to UC patients (p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: http://europepmc.org/articles/PMC2682569?pdf=render; https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0005641
URL الوصول: https://doaj.org/article/f2bf05443f4a41ee8058bed52932fb1d
رقم الأكسشن: edsdoj.f2bf05443f4a41ee8058bed52932fb1d
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0005641