دورية أكاديمية
MAPK/ERK Signaling in Regulation of Renal Differentiation
| العنوان: | MAPK/ERK Signaling in Regulation of Renal Differentiation |
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| المؤلفون: | Kristen Kurtzeborn, Hyuk Nam Kwon, Satu Kuure |
| المصدر: | International Journal of Molecular Sciences, Vol 20, Iss 7, p 1779 (2019) |
| بيانات النشر: | MDPI AG, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | extracellular signal-regulated kinase, MAPK/ERK signaling, intracellular signaling, kidney development, ureteric bud branching morphogenesis, nephrogenesis, progenitor cells, self-renewal, differentiation, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | Congenital anomalies of the kidney and urinary tract (CAKUT) are common birth defects derived from abnormalities in renal differentiation during embryogenesis. CAKUT is the major cause of end-stage renal disease and chronic kidney diseases in children, but its genetic causes remain largely unresolved. Here we discuss advances in the understanding of how mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) activity contributes to the regulation of ureteric bud branching morphogenesis, which dictates the final size, shape, and nephron number of the kidney. Recent studies also demonstrate that the MAPK/ERK pathway is directly involved in nephrogenesis, regulating both the maintenance and differentiation of the nephrogenic mesenchyme. Interestingly, aberrant MAPK/ERK signaling is linked to many cancers, and recent studies suggest it also plays a role in the most common pediatric renal cancer, Wilms’ tumor. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 20071779 |
| Relation: | https://www.mdpi.com/1422-0067/20/7/1779; https://doaj.org/toc/1422-0067 |
| DOI: | 10.3390/ijms20071779 |
| URL الوصول: | https://doaj.org/article/f2dc8b80e1df4750b8e979a18062bc27 |
| رقم الأكسشن: | edsdoj.f2dc8b80e1df4750b8e979a18062bc27 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 20071779 |
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| DOI: | 10.3390/ijms20071779 |