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'Time Is out of Joint' in Pluripotent Stem Cells: How and Why

التفاصيل البيبلوغرافية
العنوان: 'Time Is out of Joint' in Pluripotent Stem Cells: How and Why
المؤلفون: Francesca Agriesti, Olga Cela, Nazzareno Capitanio
المصدر: International Journal of Molecular Sciences, Vol 25, Iss 4, p 2063 (2024)
بيانات النشر: MDPI AG, 2024.
سنة النشر: 2024
المجموعة: LCC:Biology (General)
LCC:Chemistry
مصطلحات موضوعية: circadian rhythm, clock genes, pluripotent stem cells, reprogramming, cellular differentiation, Biology (General), QH301-705.5, Chemistry, QD1-999
الوصف: The circadian rhythm is necessary for the homeostasis and health of living organisms. Molecular clocks interconnected by transcription/translation feedback loops exist in most cells of the body. A puzzling exemption to this, otherwise, general biological hallmark is given by the cell physiology of pluripotent stem cells (PSCs) that lack circadian oscillations gradually acquired following their in vivo programmed differentiation. This process can be nicely phenocopied following in vitro commitment and reversed during the reprogramming of somatic cells to induce PSCs. The current understanding of how and why pluripotency is “time-uncoupled” is largely incomplete. A complex picture is emerging where the circadian core clockwork is negatively regulated in PSCs at the post-transcriptional/translational, epigenetic, and other-clock-interaction levels. Moreover, non-canonical functions of circadian core-work components in the balance between pluripotency identity and metabolic-driven cell reprogramming are emerging. This review selects and discusses results of relevant recent investigations providing major insights into this context.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1422-0067
1661-6596
Relation: https://www.mdpi.com/1422-0067/25/4/2063; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067
DOI: 10.3390/ijms25042063
URL الوصول: https://doaj.org/article/f374e1c4b81c41589986723a7ffc738e
رقم الأكسشن: edsdoj.f374e1c4b81c41589986723a7ffc738e
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:14220067
16616596
DOI:10.3390/ijms25042063