دورية أكاديمية
أعرض في EDS

Tumor budding and tumor‐infiltrating lymphocytes can predict prognosis in pT1b esophageal squamous cell carcinoma

التفاصيل البيبلوغرافية
العنوان: Tumor budding and tumor‐infiltrating lymphocytes can predict prognosis in pT1b esophageal squamous cell carcinoma
المؤلفون: Zhuo Li, Linxiu Liu, Bingzhi Wang, Jianming Ying, Jie He, Liyan Xue
المصدر: Thoracic Cancer, Vol 14, Iss 25, Pp 2608-2617 (2023)
بيانات النشر: Wiley, 2023.
سنة النشر: 2023
المجموعة: LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
مصطلحات موضوعية: lymph node metastasis, nomogram, prognosis, tumor budding, tumor infiltrating lymphocyte, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
الوصف: Abstract Background Tumor budding (TB) and tumor‐infiltrating lymphocyte (TIL) are significant predictive indicators of lymph node metastasis (LNM) and unfavorable prognosis in various tumors. Currently, there is no gold standard for TB and TIL evaluation in esophageal squamous cell carcinoma (ESCC). This study aimed to identify the standard of TB and TIL evaluations and build a predictive model for prognosis among patients with pT1b ESCC. Methods We retrospectively analyzed the prognostic values of TB and TIL in 150 pT1b ESCC cases. Hematoxylin and eosin (H&E) and immunohistochemistry (IHC) of anti‐pan cytokeratin (AE1/AE3) were used to analyze the threshold of TB, and intratumoral TIL and peritumoral TIL (pTIL) were evaluated using the receiver operating characteristic curves (ROC). Results We found that TB in a three‐tiered grading system (low‐TB: 0‐4; middle‐TB: 5–15; high‐TB: ≥16) displayed an excellent prognosis prediction for LNM and survival based on IHC staining using a 20× objective lens. Low pTIL level (≤20%) was a significant indicator of LNM and unfavorable prognosis (p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1759-7714
1759-7706
Relation: https://doaj.org/toc/1759-7706; https://doaj.org/toc/1759-7714
DOI: 10.1111/1759-7714.15043
URL الوصول: https://doaj.org/article/f37f76ef38ef42c4a7e0aaaf03d8c85a
رقم الأكسشن: edsdoj.f37f76ef38ef42c4a7e0aaaf03d8c85a
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:17597714
17597706
DOI:10.1111/1759-7714.15043