دورية أكاديمية
A novel reaction of peroxiredoxin 4 towards substrates in oxidative protein folding.
| العنوان: | A novel reaction of peroxiredoxin 4 towards substrates in oxidative protein folding. |
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| المؤلفون: | Li Zhu, Kai Yang, Xi'e Wang, Xi Wang, Chih-chen Wang |
| المصدر: | PLoS ONE, Vol 9, Iss 8, p e105529 (2014) |
| بيانات النشر: | Public Library of Science (PLoS), 2014. |
| سنة النشر: | 2014 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | Peroxiredoxin 4 (Prx4) is the only endoplasmic reticulum localized peroxiredoxin. It functions not only to eliminate peroxide but also to promote oxidative protein folding via oxidizing protein disulfide isomerase (PDI). In Prx4-mediated oxidative protein folding we discovered a new reaction that the sulfenic acid form of Prx4 can directly react with thiols in folding substrates, resulting in non-native disulfide cross-linking and aggregation. We also found that PDI can inhibit this reaction by exerting its reductase and chaperone activities. This discovery discloses an off-pathway reaction in the Prx4-mediated oxidative protein folding and the quality control role of PDI. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1932-6203 |
| Relation: | http://europepmc.org/articles/PMC4138195?pdf=render; https://doaj.org/toc/1932-6203 |
| DOI: | 10.1371/journal.pone.0105529 |
| URL الوصول: | https://doaj.org/article/f3896079877b4ab29a17910a3dc878be |
| رقم الأكسشن: | edsdoj.f3896079877b4ab29a17910a3dc878be |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19326203 |
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| DOI: | 10.1371/journal.pone.0105529 |