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PILRA polymorphism modifies the effect of APOE4 and GM17 on Alzheimer’s disease risk

التفاصيل البيبلوغرافية
العنوان: PILRA polymorphism modifies the effect of APOE4 and GM17 on Alzheimer’s disease risk
المؤلفون: Karin Lopatko Lindman, Caroline Jonsson, Bodil Weidung, Jan Olsson, Janardan P. Pandey, Dmitry Prokopenko, Rudolph E. Tanzi, Göran Hallmans, Sture Eriksson, Fredrik Elgh, Hugo Lövheim
المصدر: Scientific Reports, Vol 12, Iss 1, Pp 1-8 (2022)
بيانات النشر: Nature Portfolio, 2022.
سنة النشر: 2022
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: Abstract PILRA (rs1859788 A > G) has been suggested to be a protective variant for Alzheimer’s disease (AD) and is an entry co-receptor for herpes simplex virus-1. We conducted a nested case–control study of 360 1:1-matched AD subjects. Interactions between the PILRA-A allele, APOE risk variants (ε3/ε4 or ε4/ε4) and GM17 for AD risk were modelled. The associations were cross-validated using two independent whole-genome sequencing datasets. We found negative interactions between PILRA-A and GM17 (OR 0.72, 95% CI 0.52–1.00) and between PILRA-A and APOE risk variants (OR 0.56, 95% CI 0.32–0.98) in the discovery dataset. In the replication cohort, a joint effect of PILRA and PILRA × GM 17/17 was observed for the risk of developing AD (p .02). Here, we report a negative effect modification by PILRA on APOE and GM17 high-risk variants for future AD risk in two independent datasets. This highlights the complex genetics of AD.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2045-2322
Relation: https://doaj.org/toc/2045-2322
DOI: 10.1038/s41598-022-17058-6
URL الوصول: https://doaj.org/article/f3a7a1a28da34d75aad498f0901d510a
رقم الأكسشن: edsdoj.f3a7a1a28da34d75aad498f0901d510a
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20452322
DOI:10.1038/s41598-022-17058-6