دورية أكاديمية
أعرض في EDS

rs2076295 variants influence nintedanib and pirfenidone outcomes in idiopathic pulmonary fibrosis: a pilot study

التفاصيل البيبلوغرافية
العنوان: rs2076295 variants influence nintedanib and pirfenidone outcomes in idiopathic pulmonary fibrosis: a pilot study
المؤلفون: Martina Doubkova, Eva Kriegova, Simona Littnerova, Petra Schneiderova, Martina Sterclova, Vladimir Bartos, Martina Plackova, Monika Zurkova, Radka Bittenglova, Vladimira Lostaková, Lenka Siskova, Pavlina Lisa, Hana Suldova, Michael Doubek, Jana Psikalova, Tomas Snizek, Pavlina Musilova, Martina Vasakova
المصدر: Therapeutic Advances in Respiratory Disease, Vol 15 (2021)
بيانات النشر: SAGE Publishing, 2021.
سنة النشر: 2021
المجموعة: LCC:Diseases of the respiratory system
مصطلحات موضوعية: Diseases of the respiratory system, RC705-779
الوصف: Background: The antifibrotic drugs nintedanib and pirfenidone are used for the treatment of idiopathic pulmonary fibrosis (IPF). We analysed the association of common profibrotic polymorphisms in MUC5B (mucin 5B, rs35705950) and DSP (desmoplakin, rs2076295) on antifibrotic treatment outcomes in IPF. Methods: MUC5B rs35705950 and DSP rs2076295 were assessed in IPF patients ( n = 210, 139 men/71 women) from the Czech EMPIRE registry and age- or sex-matched healthy individuals ( n = 205, 125 men/80 women). Genetic data were collated with overall survival (OS), acute exacerbation episodes, worsening lung function and antifibrotic treatment. Results: We confirmed overexpression of the MUC5B rs35705950*T allele (55.2% versus 20.9%, p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1753-4666
17534666
Relation: https://doaj.org/toc/1753-4666
DOI: 10.1177/17534666211042529
URL الوصول: https://doaj.org/article/f44baceebf1c45358ab4de31e662b434
رقم الأكسشن: edsdoj.f44baceebf1c45358ab4de31e662b434
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:17534666
DOI:10.1177/17534666211042529