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SARS-CoV-2 Omicron variant: recent progress and future perspectives

التفاصيل البيبلوغرافية
العنوان: SARS-CoV-2 Omicron variant: recent progress and future perspectives
المؤلفون: Yao Fan, Xiang Li, Lei Zhang, Shu Wan, Long Zhang, Fangfang Zhou
المصدر: Signal Transduction and Targeted Therapy, Vol 7, Iss 1, Pp 1-11 (2022)
بيانات النشر: Nature Publishing Group, 2022.
سنة النشر: 2022
المجموعة: LCC:Medicine
LCC:Biology (General)
مصطلحات موضوعية: Medicine, Biology (General), QH301-705.5
الوصف: Abstract Since the outbreak of the coronavirus disease 2019 (COVID-19) pandemic, there have been a few variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), one of which is the Omicron variant (B.1.1.529). The Omicron variant is the most mutated SARS-CoV-2 variant, and its high transmissibility and immune evasion ability have raised global concerns. Owing to its enhanced transmissibility, Omicron has rapidly replaced Delta as the dominant variant in several regions. However, recent studies have shown that the Omicron variant exhibits reduced pathogenicity due to altered cell tropism. In addition, Omicron exhibits significant resistance to the neutralizing activity of vaccines, convalescent serum, and most antibody therapies. In the present review, recent advances in the molecular and clinical characteristics of the infectivity, pathogenicity, and immune evasion of Omicron variant was summarized, and potential therapeutic applications in response to Omicron infection were discussed. Furthermore, we highlighted potential response to future waves and strategies to end the pandemic.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2059-3635
Relation: https://doaj.org/toc/2059-3635
DOI: 10.1038/s41392-022-00997-x
URL الوصول: https://doaj.org/article/f465a5ce7d434eb5ad0d8f5009c0f92c
رقم الأكسشن: edsdoj.f465a5ce7d434eb5ad0d8f5009c0f92c
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20593635
DOI:10.1038/s41392-022-00997-x