دورية أكاديمية
The clinical prognostic value of lncRNA FAM83H-AS1 in cancer patients: a meta-analysis
| العنوان: | The clinical prognostic value of lncRNA FAM83H-AS1 in cancer patients: a meta-analysis |
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| المؤلفون: | Qin Yang, Jie Wang, Pingyong Zhong, Tinggang Mou, Hao Hua, Pan Liu, Fei Xie |
| المصدر: | Cancer Cell International, Vol 20, Iss 1, Pp 1-11 (2020) |
| بيانات النشر: | BMC, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens LCC:Cytology |
| مصطلحات موضوعية: | Cancer, Overall survival, Prognosis, Long non-coding RNA, FAM83H-AS1, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671 |
| الوصف: | Abstract Background Family with sequence similarity 83 member H antisense RNA 1 (FAM83H-AS1) is a novel long non-coding RNA. Increasing studies have reported that FAM83H-AS1 is abnormally expressed in a variety of tumors and is associated with poor outcome. However, the clinical prognostic significance of lncRNA FAM83H-AS1 in tumors is not completely known. Methods In this meta-analysis, literature was collected up until February 5, 2020 through multifarious retrieval strategies by searching through electronic databases of PubMed, Cochrane Library, EMBASE, Medline, Web of Science, CNKI, Weipu, and Wanfang. A total of 14 studies that met the inclusion criteria with relevant clinical data and prognostic information were included in the meta-analysis. Results The combined results revealed that high expression of FAM83H-AS1 was associated with poor overall survival (OS) (HR = 1.63, 95% CI 1.24–2.14, P = 0.0004) in a variety of cancers. Additionally, upregulated FAM83H-AS1 expression was significantly correlated with tumor TNM stage (III/IV vs. I/II, OR = 2.40, 95% CI 1.36–4.23, P = 0.003) and lymph node metastasis (positive vs. negative, OR = 1.70, 95% CI 1.14–2.52, P = 0.008) in patients with cancer. Conclusions Our results of this meta-analysis indicated that elevated FAM83H-AS1 expression could predict poor prognosis in patients with cancer and suggested that FAM83H-AS1 might serve as a novel biomarker for cancer. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1475-2867 |
| Relation: | http://link.springer.com/article/10.1186/s12935-020-1148-8; https://doaj.org/toc/1475-2867 |
| DOI: | 10.1186/s12935-020-1148-8 |
| URL الوصول: | https://doaj.org/article/f465ff7f567945caa7dfe2a124531cf1 |
| رقم الأكسشن: | edsdoj.f465ff7f567945caa7dfe2a124531cf1 |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 14752867 |
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| DOI: | 10.1186/s12935-020-1148-8 |