MYCN-driven fatty acid uptake is a metabolic vulnerability in neuroblastoma

التفاصيل البيبلوغرافية
العنوان:	MYCN-driven fatty acid uptake is a metabolic vulnerability in neuroblastoma
المؤلفون:	Ling Tao, Mahmoud A. Mohammad, Giorgio Milazzo, Myrthala Moreno-Smith, Tajhal D. Patel, Barry Zorman, Andrew Badachhape, Blanca E. Hernandez, Amber B. Wolf, Zihua Zeng, Jennifer H. Foster, Sara Aloisi, Pavel Sumazin, Youli Zu, John Hicks, Ketan B. Ghaghada, Nagireddy Putluri, Giovanni Perini, Cristian Coarfa, Eveline Barbieri
المصدر:	Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
بيانات النشر:	Nature Portfolio, 2022.
سنة النشر:	2022
المجموعة:	LCC:Science
مصطلحات موضوعية:	Science
الوصف:	Half of high-risk neuroblastoma patients have MYCN amplification. Here, the authors show that MYCN induces fatty acid uptake and synthesis to support neuroblastoma and inhibition of a fatty acid transporter impairs tumor progression in preclinical models.
نوع الوثيقة:	article
وصف الملف:	electronic resource
اللغة:	English
تدمد:	2041-1723
Relation:	https://doaj.org/toc/2041-1723
DOI:	10.1038/s41467-022-31331-2
URL الوصول:	https://doaj.org/article/f46634316a174b53a1daa084ab8c5d23
رقم الأكسشن:	edsdoj.f46634316a174b53a1daa084ab8c5d23
قاعدة البيانات:	Directory of Open Access Journals

الوصف
تدمد:	20411723
DOI:	10.1038/s41467-022-31331-2