دورية أكاديمية
Obtaining and Immunologic Characterization of Filoviruses Recombinant Proteins VP40 and NP
| العنوان: | Obtaining and Immunologic Characterization of Filoviruses Recombinant Proteins VP40 and NP |
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| المؤلفون: | A. V. Ivanova, E. I. Kazachinskaya, A. V. Kachko, E. L. Subbotina, A. V. Sorokin, I. A. Razumov, S. V. Neteosov, V. B. Loktev |
| المصدر: | Проблемы особо опасных инфекций, Vol 0, Iss 4(106), Pp 32-36 (2010) |
| بيانات النشر: | Federal Government Health Institution, Russian Research Anti-Plague Institute “Microbe”, 2010. |
| سنة النشر: | 2010 |
| المجموعة: | LCC:Infectious and parasitic diseases |
| مصطلحات موضوعية: | marburg virus (mv), ebola virus (ev), recombinant proteins, Infectious and parasitic diseases, RC109-216 |
| الوصف: | Full-size genes coding matrix proteins VP40 of Ebola virus (VE) and Marburg virus (VM) and nucleoprotein (NP) of VE were cloned. These genes expression in Escherichia coli and purification of their products by affinity chromatography using Ni-NTA agarose permitted to obtain full-size recombinant VP40 and NP proteins of filoviruses. Immunological studies showed the recombinant polypeptides to possess antigenic properties similar to those of the native viral proteins. These proteins can be used for constructing of experimental vaccines against filoviruses and improving immunodiagnostic tests against filoviral infections. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | Russian |
| تدمد: | 0370-1069 2658-719X |
| Relation: | https://journal.microbe.ru/jour/article/view/560; https://doaj.org/toc/0370-1069; https://doaj.org/toc/2658-719X |
| DOI: | 10.21055/0370-1069-2010-4(106)-32-36 |
| URL الوصول: | https://doaj.org/article/f470d098eebe42668bbf2850bdffcce3 |
| رقم الأكسشن: | edsdoj.f470d098eebe42668bbf2850bdffcce3 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 03701069 2658719X |
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| DOI: | 10.21055/0370-1069-2010-4(106)-32-36 |