دورية أكاديمية
Role of interleukin-6 signaling pathway in adverse health effects induced by air pollution
| العنوان: | Role of interleukin-6 signaling pathway in adverse health effects induced by air pollution |
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| المؤلفون: | Wenpu SHAO, Renzhen PENG, Yanyi XU |
| المصدر: | 环境与职业医学, Vol 40, Iss 3, Pp 355-361 (2023) |
| بيانات النشر: | Editorial Committee of Journal of Environmental and Occupational Medicine, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Medicine (General) LCC:Toxicology. Poisons |
| مصطلحات موضوعية: | air pollution, interleukin-6, signaling pathway, respiratory system, toxicological effect, molecular mechanism, Medicine (General), R5-920, Toxicology. Poisons, RA1190-1270 |
| الوصف: | Air pollution is one of the most important environmental issues in China and worldwide, as well as a critical public health problem affecting human health. With the implementation of emission reduction and other programs, the air quality in China has been improved dramatically in recent years, but is still worse than the WHO guideline recommended levels. Numerous epidemiological and toxicological studies have shown that short-term or long-term exposure to air pollution is strongly associated with respiratory diseases, cardiovascular diseases, diabetes, and so forth, in which interleukin-6 (IL-6), a well-known inflammatory factor, may play an important role. Studies have found that IL-6 can bind to interleukin-6 receptor (IL-6R) , which leads to the recruiting and activation of glycoprotein 130, and then the formed IL-6/IL-6R/gp130 complex triggers the janus kinase/signal transducer and activator of transcription, Src homology-2 domain-containing protein tyrosine phosphatase-2/mitogen-activated protein kinase, and phosphatidylinositol 3-kinase/protein kinase B signaling pathways. All of these signaling pathways are found to be involved in a variety of physiopathological processes. In the present review, information about the IL-6 signaling pathway and its role in air pollution-induced adverse health effects was systematically reviewed, hoping to provide insights for the future prevention and control policies. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English Chinese |
| تدمد: | 2095-9982 |
| Relation: | http://www.jeom.org/article/cn/10.11836/JEOM22344; https://doaj.org/toc/2095-9982 |
| DOI: | 10.11836/JEOM22344 |
| URL الوصول: | https://doaj.org/article/f4745a5ca45641649234f84dbf61edc0 |
| رقم الأكسشن: | edsdoj.f4745a5ca45641649234f84dbf61edc0 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20959982 |
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| DOI: | 10.11836/JEOM22344 |