دورية أكاديمية
Biomarkers of axonal damage to favor early diagnosis in variant transthyretin amyloidosis (A-ATTRv)
| العنوان: | Biomarkers of axonal damage to favor early diagnosis in variant transthyretin amyloidosis (A-ATTRv) |
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| المؤلفون: | Juan González-Moreno, Álvaro Gragera-Martínez, Adrián Rodríguez, Cristina Borrachero-Garro, Sandra García-Garrido, Carles Barceló, Ana Manovel-Sánchez, Maria Antonia Ribot-Sansó, Lesly Ibargüen-González, Rosa Gomila, Francisco Muñoz-Beamud, Inés Losada-López, Eugenia Cisneros-Barroso |
| المصدر: | Scientific Reports, Vol 14, Iss 1, Pp 1-8 (2024) |
| بيانات النشر: | Nature Portfolio, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | Abstract Early identification of ATTRv amyloidosis disease onset is still often delayed due to the lack of validated biomarkers of this disease. Light chain neurofilament (NfL) have shown promising results in early diagnosis in this disease, but data is still needed, including with alternative measuring methods. Our aim was to study the levels of NfL measured by ELISA. Furthermore, interstitial matrix metalloproteinase type 1 (MMP-1) serum levels were measured as a potential new biomarker in ATTRv. Serum NfL and MMP-1 were measured using ELISA assays in 90 participants (29 ATTR-V30M patients, 31 asymptomatic V30M-TTR variant carriers and 30 healthy controls). Median NfL levels among ATTRv amyloidosis patients were significantly higher (116 pg/mL vs 0 pg/mL in both comparison groups). The AUC comparing ATTRv amyloidosis patients and asymptomatic carriers was 0.90 and the NfL concentration of 93.55 pg/mL yielded a sensitivity of 79% and a specificity of 87%. NfL levels had a significant positive correlation with NIS values among patients. We found a negative significant correlation between eGFR and NfL levels. Finally, MMP1 levels were not different between groups. Evidence of NfL use for early diagnosis of ATTR-PN amyloidosis is growing. ELISA seems a reliable and available technique for it quantification. Decreased GFR could influence NfL plasma levels. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2045-2322 |
| Relation: | https://doaj.org/toc/2045-2322 |
| DOI: | 10.1038/s41598-023-50212-2 |
| URL الوصول: | https://doaj.org/article/f491e56deaff4e268c5c6c466f3a8c66 |
| رقم الأكسشن: | edsdoj.f491e56deaff4e268c5c6c466f3a8c66 |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 20452322 |
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| DOI: | 10.1038/s41598-023-50212-2 |