دورية أكاديمية
Radiotherapy-sensitized cancer immunotherapy via cGAS-STING immune pathway by activatable nanocascade reaction
العنوان: | Radiotherapy-sensitized cancer immunotherapy via cGAS-STING immune pathway by activatable nanocascade reaction |
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المؤلفون: | Honglei Hu, Shuting Zheng, Chenxi He, Yinfei Zheng, Qiming Wei, Siwen Chen, Zede Wu, Yikai Xu, Bingxia Zhao, Chenggong Yan |
المصدر: | Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-16 (2024) |
بيانات النشر: | BMC, 2024. |
سنة النشر: | 2024 |
المجموعة: | LCC:Biotechnology LCC:Medical technology |
مصطلحات موضوعية: | cGAS-STING, Ferroptosis, Radiotherapy sensitization, Theranostics, Molecular imaging, Biotechnology, TP248.13-248.65, Medical technology, R855-855.5 |
الوصف: | Abstract Radiotherapy-induced immune activation holds great promise for optimizing cancer treatment efficacy. Here, we describe a clinically used radiosensitizer hafnium oxide (HfO2) that was core coated with a MnO2 shell followed by a glucose oxidase (GOx) doping nanoplatform (HfO2@MnO2@GOx, HMG) to trigger ferroptosis adjuvant effects by glutathione depletion and reactive oxygen species production. This ferroptosis cascade potentiation further sensitized radiotherapy by enhancing DNA damage in 4T1 breast cancer tumor cells. The combination of HMG nanoparticles and radiotherapy effectively activated the damaged DNA and Mn2+-mediated cGAS-STING immune pathway in vitro and in vivo. This process had significant inhibitory effects on cancer progression and initiating an anticancer systemic immune response to prevent distant tumor recurrence and achieve long-lasting tumor suppression of both primary and distant tumors. Furthermore, the as-prepared HMG nanoparticles “turned on” spectral computed tomography (CT)/magnetic resonance dual-modality imaging signals, and demonstrated favorable contrast enhancement capabilities activated by under the GSH tumor microenvironment. This result highlighted the potential of nanoparticles as a theranostic nanoplatform for achieving molecular imaging guided tumor radiotherapy sensitization induced by synergistic immunotherapy. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 1477-3155 |
Relation: | https://doaj.org/toc/1477-3155 |
DOI: | 10.1186/s12951-024-02502-8 |
URL الوصول: | https://doaj.org/article/f4df5d0cab2a413183755fd66afba74d |
رقم الأكسشن: | edsdoj.f4df5d0cab2a413183755fd66afba74d |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 14773155 |
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DOI: | 10.1186/s12951-024-02502-8 |