دورية أكاديمية

Development and validation of cognitive ageing risk score (CARS) for early detection of subtle cognitive deficits in older people

التفاصيل البيبلوغرافية
العنوان: Development and validation of cognitive ageing risk score (CARS) for early detection of subtle cognitive deficits in older people
المؤلفون: Ada Wai Tung Fung, Allen Ting Chun Lee, Suk Ling Ma, Linda Chiu Wa Lam
المصدر: BMC Geriatrics, Vol 24, Iss 1, Pp 1-9 (2024)
بيانات النشر: BMC, 2024.
سنة النشر: 2024
المجموعة: LCC:Geriatrics
مصطلحات موضوعية: Dementia risk, Early cognitive deficits, Vascular risks, Psychosocial risks, Lifestyle intervention, Alzheimer’s disease, Geriatrics, RC952-954.6
الوصف: Abstract Background Early cognitive deficits commonly seen in older people have not been well defined and managed in primary care. The objectives are (1) to develop and validate a new risk score to estimate the risk of dementia in Chinese older population; and (2) to evaluate the use of risk score in conjunction with cognitive screening in detecting early cognitive deficits in community older people. Methods A development cohort of 306 cognitive healthy older adults aged 60 or above were followed for 6 years. A CARS was constructed using the estimated coefficients of risk factors associated with dementia at follow up. Validation was carried out in another five-year cohort of 383 older adults. The usefulness of CARS in detecting early cognitive deficits was evaluated. Results Risk factors include older age, male gender, low level of education, poorly controlled diabetes, prolonged sleep latency, fewer mind body or light exercise, loneliness, and being apolipoprotein e4 carriers. A cutoff of CARS at -1.3 had a sensitivity of 83.9% and a specificity of 75.4% to predict dementia. The area under curve was 82.5% in the development cohort. Early cognitive deficits were characterized by impaired retention (p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1471-2318
Relation: https://doaj.org/toc/1471-2318
DOI: 10.1186/s12877-024-04879-5
URL الوصول: https://doaj.org/article/f51d4b6e57f547d69ea936af13fe1377
رقم الأكسشن: edsdoj.f51d4b6e57f547d69ea936af13fe1377
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:14712318
DOI:10.1186/s12877-024-04879-5