دورية أكاديمية
Comparison of intraperitoneal honey and sodium hyaluronate-carboxymethylcellulose (SeprafilmTM) for the prevention of postoperative intra-abdominal adhesions
| العنوان: | Comparison of intraperitoneal honey and sodium hyaluronate-carboxymethylcellulose (SeprafilmTM) for the prevention of postoperative intra-abdominal adhesions |
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| المؤلفون: | Arif Emre, Murat Akin, Ipek Isikgonul, Osman Yuksel, Ahmet Ziya Anadol, Cagatay Cifter |
| المصدر: | Clinics, Vol 64, Iss 4, Pp 363-368 (2009) |
| بيانات النشر: | Elsevier España, 2009. |
| سنة النشر: | 2009 |
| المجموعة: | LCC:Medicine (General) |
| مصطلحات موضوعية: | Postoperative intra-abdominal adhesions, Seprafilm, Honey, Rat, Cecal abrasion, Medicine (General), R5-920 |
| الوصف: | BACKGROUND: Abdominal surgery can lead to postoperative intra-abdominal adhesions (PIAAs) with significant morbidity and mortality. This study compares the use of honey with a standard bioresorbable membrane (Seprafilm tm) to prevent the formation of PIAAs in rats. METHODS: Thirty rats underwent laparotomy, and PIAAs were induced by scraping the cecum. The animals were divided into three groups, each containing ten rats. Group 1 (control) represented the cecal abrasion group, with no intraperitoneal administration of any substance. Group 2 (honey group) underwent cecal abrasion and intraperitoneal administration of honey. Group 3 (Seprafilm tm group) underwent cecal abrasion and intraperitoneal Seprafilm tm application. RESULTS: Group 1 exhibited higher adhesion scores for adhesions between the abdominal wall and the organs. Groups 2 and 3 had decreased adhesive attachments to the intra-abdominal structures. Compared to group 1, the incidence of adhesion formation was lower in both group 2 (p=0.001) and group 3 (p=0.001). The incidence of fibrosis was also lower in group 2 (p=0.016) and group 3 (p=0.063) compared to group 1. There was no significant difference between the histopathological fibrosis scores for the rats in group 2 and those in group 3 (p= 0.688). CONCLUSION: This study suggests that both honey and Seprafilm tm decrease the incidence of PIAAs in the rat cecal abrasion model. Although the mechanism of action is not clear, intraperitoneal administration of honey reduced PIAAs. The outcome of this study demonstrates that honey is as effective as Seprafilm tm in preventing PIAAs. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1807-5932 1980-5322 |
| Relation: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322009000400016; https://doaj.org/toc/1807-5932; https://doaj.org/toc/1980-5322 |
| DOI: | 10.1590/S1807-59322009000400016 |
| URL الوصول: | https://doaj.org/article/f54f1f0b4c2b469aadf06acf0874a24e |
| رقم الأكسشن: | edsdoj.f54f1f0b4c2b469aadf06acf0874a24e |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 18075932 19805322 |
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| DOI: | 10.1590/S1807-59322009000400016 |