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The glycosphingolipid MacCer promotes synaptic bouton formation in Drosophila by interacting with Wnt

التفاصيل البيبلوغرافية
العنوان: The glycosphingolipid MacCer promotes synaptic bouton formation in Drosophila by interacting with Wnt
المؤلفون: Yan Huang, Sheng Huang, Coralie Di Scala, Qifu Wang, Hans H Wandall, Jacques Fantini, Yong Q Zhang
المصدر: eLife, Vol 7 (2018)
بيانات النشر: eLife Sciences Publications Ltd, 2018.
سنة النشر: 2018
المجموعة: LCC:Medicine
LCC:Science
LCC:Biology (General)
مصطلحات موضوعية: Glycosphingolipid, synaptic growth, Wnt signaling, lipid-protein interaction, Medicine, Science, Biology (General), QH301-705.5
الوصف: Lipids are structural components of cellular membranes and signaling molecules that are widely involved in development and diseases, but the underlying molecular mechanisms are poorly understood, partly because of the vast variety of lipid species and complexity of synthetic and turnover pathways. From a genetic screen, we identify that mannosyl glucosylceramide (MacCer), a species of glycosphingolipid (GSL), promotes synaptic bouton formation at the Drosophila neuromuscular junction (NMJ). Pharmacological and genetic analysis shows that the NMJ growth-promoting effect of MacCer depends on normal lipid rafts, which are known to be composed of sphingolipids, sterols and select proteins. MacCer positively regulates the synaptic level of Wnt1/Wingless (Wg) and facilitates presynaptic Wg signaling, whose activity is raft-dependent. Furthermore, a functional GSL-binding motif in Wg exhibiting a high affinity for MacCer is required for normal NMJ growth. These findings reveal a novel mechanism whereby the GSL MacCer promotes synaptic bouton formation via Wg signaling.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2050-084X
Relation: https://elifesciences.org/articles/38183; https://doaj.org/toc/2050-084X
DOI: 10.7554/eLife.38183
URL الوصول: https://doaj.org/article/af56abc4cef34d6ba99c67a683c3f88b
رقم الأكسشن: edsdoj.f56abc4cef34d6ba99c67a683c3f88b
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:2050084X
DOI:10.7554/eLife.38183