دورية أكاديمية
Long noncoding RNA SBF2-AS1 act as a ceRNA to modulate cell proliferation via binding with miR-188-5p in acute myeloid leukemia
العنوان: | Long noncoding RNA SBF2-AS1 act as a ceRNA to modulate cell proliferation via binding with miR-188-5p in acute myeloid leukemia |
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المؤلفون: | Yun-Jiao Tian, Yan-Hua Wang, Ai-Ju Xiao, Pei-Ling Li, Jia Guo, Tuan-Jie Wang, Dong-Ju Zhao |
المصدر: | Artificial Cells, Nanomedicine, and Biotechnology, Vol 47, Iss 1, Pp 1730-1737 (2019) |
بيانات النشر: | Taylor & Francis Group, 2019. |
سنة النشر: | 2019 |
المجموعة: | LCC:Biotechnology LCC:Medical technology |
مصطلحات موضوعية: | Acute myeloid leukemia, lncRNA SBF2-AS1, miR-188-5p, ZFP91, Biotechnology, TP248.13-248.65, Medical technology, R855-855.5 |
الوصف: | LncRNA SBF2-AS1 has been reported to be implicated in the deterioration of multiple human cancers. However, the roles and underlying mechanisms of SBF2-AS1 in acute myeloid leukemia (AML) are still unclear. In the present study, the online GEPIA database showed that SBF2-AS1 expression was significantly increased in AML samples. QRT-PCR results showed that SBF2-AS1 expression was upregulated in AML cells. CCK-8 assay revealed that SBF2-AS1 inhibition decreased AML cells proliferation ability in vitro. Flow cytometry assays showed that SBF2-AS1 inhibition induced AML cells apoptosis and arrested AML cells in G0/G1 phase. Mechanistically, miR-188-5p was identified as a direct target of SBF2-AS1. SBF2-AS1 upregulated the expression level of ZFP91 by sponging miR-188-5p. And the effects of SBF2-AS1 suppression on AML cells progression could be abolished by miR-188-5p inhibitors. Moreover, we found that SBF2-AS1 inhibition reduced tumor growth in vivo. Taken together, our findings elucidated that SBF2-AS1 could act as a miRNA sponge in AML progression, and provided a potential therapeutic strategy for AML treatment. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 21691401 2169-141X 2169-1401 |
Relation: | https://doaj.org/toc/2169-1401; https://doaj.org/toc/2169-141X |
DOI: | 10.1080/21691401.2019.1608221 |
URL الوصول: | https://doaj.org/article/ef58651c17b44acb8b252dfd9adf133a |
رقم الأكسشن: | edsdoj.f58651c17b44acb8b252dfd9adf133a |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 21691401 2169141X |
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DOI: | 10.1080/21691401.2019.1608221 |