دورية أكاديمية
Evaluating the utility of knowledge-based planning for clinical trials using the TROG 08.03 post prostatectomy radiation therapy planning data
| العنوان: | Evaluating the utility of knowledge-based planning for clinical trials using the TROG 08.03 post prostatectomy radiation therapy planning data |
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| المؤلفون: | Kirsten van Gysen, Andrew Kneebone, Andrew Le, Kenny Wu, Annette Haworth, Regina Bromley, George Hruby, James O'Toole, Jeremy Booth, Chris Brown, Maria Pearse, Mark Sidhom, Kirsty Wiltshire, Colin Tang, Thomas Eade |
| المصدر: | Physics and Imaging in Radiation Oncology, Vol 22, Iss , Pp 91-97 (2022) |
| بيانات النشر: | Elsevier, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Medical physics. Medical radiology. Nuclear medicine LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | Post-prostatectomy radiation therapy, Quality assurance, Knowledge-based planning, TROG 08.03, Medical physics. Medical radiology. Nuclear medicine, R895-920, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Background and purpose: Poor quality radiotherapy can detrimentally affect outcomes in clinical trials. Our purpose was to explore the potential of knowledge-based planning (KBP) for quality assurance (QA) in clinical trials. Materials and methods: Using 30 in-house post-prostatectomy radiation treatment (PPRT) plans, an iterative KBP model was created according to the multicentre clinical trial protocol, delivering 64 Gy in 32 fractions. KBP was used to replan 137 plans. The KB (knowledge based) plans were evaluated for their ability to fulfil the trial constraints and were compared against their corresponding original treatment plans (OTP). A second analysis between only the 72 inversely planned OTPs (IP-OTPs) and their corresponding KB plans was performed. Results: All dose constraints were met in 100% of KB plans versus 69% of OTPs. KB plans demonstrated significantly less variation in PTV coverage (Mean dose range: KB plans 64.1 Gy-65.1 Gy vs OTP 63.1 Gy-67.3 Gy, p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2405-6316 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2405631622000446; https://doaj.org/toc/2405-6316 |
| DOI: | 10.1016/j.phro.2022.05.004 |
| URL الوصول: | https://doaj.org/article/af598592308a4337998c0221c9aa5f13 |
| رقم الأكسشن: | edsdoj.f598592308a4337998c0221c9aa5f13 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 24056316 |
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| DOI: | 10.1016/j.phro.2022.05.004 |