دورية أكاديمية
Muscle insulin-like growth factor-I modulates murine craniofacial bone growth
| العنوان: | Muscle insulin-like growth factor-I modulates murine craniofacial bone growth |
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| المؤلفون: | HJ Kok, CN Crowder, L Koo Min Chee, HY Choi, N Lin, ER Barton |
| المصدر: | European Cells & Materials, Vol 42, Pp 72-89 (2021) |
| بيانات النشر: | Forum Multimedia Publishing LLC, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Diseases of the musculoskeletal system LCC:Orthopedic surgery |
| مصطلحات موضوعية: | muscle-bone interaction, insulin-like growth factor i, craniofacial, Diseases of the musculoskeletal system, RC925-935, Orthopedic surgery, RD701-811 |
| الوصف: | Insulin-like growth factor I (IGF-I) is essential for muscle and bone development and a primary mediator of growth hormone (GH) actions. While studies have elucidated the importance of IGF-I specifically in muscle or bone development, few studies to date have evaluated the relationship between muscle and bone modulated by IGF-I in vivo, during post-natal growth. Mice with muscle-specific IGF-I overexpression (mIgf1+/+) were utilised to determine IGF-I- and muscle-mass-dependent effects on craniofacial skeleton development during post-natal growth. mIgf1+/+ mice displayed accelerated craniofacial bone growth when compared to wild-type animals. Virus-mediated expression of IGF-I targeting the masseter was performed to determine if post-natal modulation of IGF-I altered mandibular structures. Increased IGF-I in the masseter affected the mandibular base plane angle in a lateral manner, increasing the width of the mandible. At the cellular level, increased muscle IGF-I also accelerated cartilage thickness in the mandibular condyle. Importantly, mandibular length changes associated with increased IGF-I were not present in mice with genetic inhibition of muscle IGF-I receptor activity. These results demonstrated that muscle IGF-I could indirectly affect craniofacial growth through IGF-I-dependent increases in muscle hypertrophy. These findings have clinical implications when considering IGF-I as a therapeutic strategy for craniofacial disorders. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1473-2262 |
| Relation: | https://www.ecmjournal.org/papers/vol042/pdf/v042a06.pdf; https://doaj.org/toc/1473-2262 |
| DOI: | 10.22203/eCM.v042a06 |
| URL الوصول: | https://doaj.org/article/f5a8b122e7294dacb5f73c977854e9fb |
| رقم الأكسشن: | edsdoj.f5a8b122e7294dacb5f73c977854e9fb |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14732262 |
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| DOI: | 10.22203/eCM.v042a06 |