دورية أكاديمية
Stem cell-laden hydrogel bioink for generation of high resolution and fidelity engineered tissues with complex geometries
| العنوان: | Stem cell-laden hydrogel bioink for generation of high resolution and fidelity engineered tissues with complex geometries |
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| المؤلفون: | Oju Jeon, Yu Bin Lee, Sang Jin Lee, Nazilya Guliyeva, Joanna Lee, Eben Alsberg |
| المصدر: | Bioactive Materials, Vol 15, Iss , Pp 185-193 (2022) |
| بيانات النشر: | KeAi Communications Co., Ltd., 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Materials of engineering and construction. Mechanics of materials LCC:Biology (General) |
| مصطلحات موضوعية: | 3D bioprinting, Hydrogel bioink, Biomaterial, High resolution and fidelity, Materials of engineering and construction. Mechanics of materials, TA401-492, Biology (General), QH301-705.5 |
| الوصف: | Recently, 3D bioprinting has been explored as a promising technology for biomedical applications with the potential to create complex structures with precise features. Cell encapsulated hydrogels composed of materials such as gelatin, collagen, hyaluronic acid, alginate and polyethylene glycol have been widely used as bioinks for 3D bioprinting. However, since most hydrogel-based bioinks may not allow rapid stabilization immediately after 3D bioprinting, achieving high resolution and fidelity to the intended architecture is a common challenge in 3D bioprinting of hydrogels. In this study, we have utilized shear-thinning and self-healing ionically crosslinked oxidized and methacrylated alginates (OMAs) as a bioink, which can be rapidly gelled by its self-healing property after bioprinting and further stabilized via secondary crosslinking. It was successfully demonstrated that stem cell-laden calcium-crosslinked OMA hydrogels can be bioprinted into complicated 3D tissue structures with both high resolution and fidelity. Additional photocrosslinking enables long-term culture of 3D bioprinted constructs for formation of functional tissue by differentiation of encapsulated human mesenchymal stem cells. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2452-199X |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2452199X21005557; https://doaj.org/toc/2452-199X |
| DOI: | 10.1016/j.bioactmat.2021.11.025 |
| URL الوصول: | https://doaj.org/article/f5f647f099b743bda2d049da4b9cd92d |
| رقم الأكسشن: | edsdoj.f5f647f099b743bda2d049da4b9cd92d |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 2452199X |
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| DOI: | 10.1016/j.bioactmat.2021.11.025 |