دورية أكاديمية
Epigenetic Signatures in Arterial Hypertension: Focus on the Microvasculature
| العنوان: | Epigenetic Signatures in Arterial Hypertension: Focus on the Microvasculature |
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| المؤلفون: | Alessandro Mengozzi, Sarah Costantino, Alessia Mongelli, Shafeeq A. Mohammed, Era Gorica, Valentina Delfine, Stefano Masi, Agostino Virdis, Frank Ruschitzka, Francesco Paneni |
| المصدر: | International Journal of Molecular Sciences, Vol 24, Iss 5, p 4854 (2023) |
| بيانات النشر: | MDPI AG, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | arterial hypertension, epigenetics, microcirculation, endothelial cells, vascular smooth muscle cells, perivascular adipose tissue, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | Systemic arterial hypertension (AH) is a multifaceted disease characterized by accelerated vascular aging and high cardiometabolic morbidity and mortality. Despite extensive work in the field, the pathogenesis of AH is still incompletely understood, and its treatment remains challenging. Recent evidence has shown a deep involvement of epigenetic signals in the regulation of transcriptional programs underpinning maladaptive vascular remodeling, sympathetic activation and cardiometabolic alterations, all factors predisposing to AH. After occurring, these epigenetic changes have a long-lasting effect on gene dysregulation and do not seem to be reversible upon intensive treatment or the control of cardiovascular risk factors. Among the factors involved in arterial hypertension, microvascular dysfunction plays a central role. This review will focus on the emerging role of epigenetic changes in hypertensive-related microvascular disease, including the different cell types and tissues (endothelial cells, vascular smooth muscle cells and perivascular adipose tissue) as well as the involvement of mechanical/hemodynamic factors, namely, shear stress. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| Relation: | https://www.mdpi.com/1422-0067/24/5/4854; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067 |
| DOI: | 10.3390/ijms24054854 |
| URL الوصول: | https://doaj.org/article/f5fcd41f79ff407f91f0ecbc71d3c8df |
| رقم الأكسشن: | edsdoj.f5fcd41f79ff407f91f0ecbc71d3c8df |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 16616596 |
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| DOI: | 10.3390/ijms24054854 |