دورية أكاديمية
Effect of lncRNA LINC00324 on cervical cancer progression through down-regulation of miR-195-5p
| العنوان: | Effect of lncRNA LINC00324 on cervical cancer progression through down-regulation of miR-195-5p |
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| المؤلفون: | Suna Ni, Zhixia Wei, Dandan Li |
| المصدر: | Journal of Obstetrics and Gynaecology, Vol 43, Iss 2 (2023) |
| بيانات النشر: | Taylor & Francis Group, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Gynecology and obstetrics |
| مصطلحات موضوعية: | lncRNA LINC00324, cervical cancer, miR-195-5p, Gynecology and obstetrics, RG1-991 |
| الوصف: | AbstractBackground Long non-coding RNAs (lncRNAs) have been widely used in the exploration of diseases in recent years. This paper introduced the significance of lncRNA LINC00324 (LINC00324) on the progression of cervical cancer and explored the mechanism of action and potential prognosis of LINC00324.Methods The cervical cancer tissues and adjacent normal tissues of 120 people were collected as research samples. The expression level of LINC00324 was assessed by RT-qPCR, as was miR-195-5p. Knockdown of LINC00324 on the proliferation ability of cervical cancer cells was determined with the help of cell counting kit-8 (CCK-8), and the number of cell migration and invasion was detected by the Transwell method. Luciferase reporter gene assay was used to analyse the correlation of LINC00324 and miR-195-5p. Kaplan–Meier survival curves and multivariate Cox analysis explained the potential prognostic significance of LINC00324 in cervical cancer.Results Significantly increased expression of LINC00324 and down-regulated miR-195-5p were negatively correlated in cervical cancer. Knockdown of LINC00324 inhibited the progression of cervical cancer, which was related to its mechanism of targeting and downregulating miR-195-5p. In addition, low expression of LINC00324 may prolong the survival period of patients with cervical cancer.Conclusions LINC00324 targets miR-195-5p to regulate the progression of cervical cancer and have potential as a prognostic molecular marker for cervical cancer. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 01443615 1364-6893 0144-3615 |
| Relation: | https://doaj.org/toc/0144-3615; https://doaj.org/toc/1364-6893 |
| DOI: | 10.1080/01443615.2023.2285384 |
| URL الوصول: | https://doaj.org/article/f60420ad546744e0a36804e9dedfe5e1 |
| رقم الأكسشن: | edsdoj.f60420ad546744e0a36804e9dedfe5e1 |
| قاعدة البيانات: | Directory of Open Access Journals |
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Full Text Finder | تدمد: | 01443615 13646893 |
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| DOI: | 10.1080/01443615.2023.2285384 |