دورية أكاديمية
Effects of 5-hydroxytryptamine on spermatozoal hyperactivation and in vitro fertilization in mice
| العنوان: | Effects of 5-hydroxytryptamine on spermatozoal hyperactivation and in vitro fertilization in mice |
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| المؤلفون: | Yukiko SUGIYAMA, Masakatsu FUJINOKI, Hiroaki SHIBAHARA |
| المصدر: | The Journal of Reproduction and Development, Vol 65, Iss 6, Pp 541-550 (2019) |
| بيانات النشر: | The Society for Reproduction and Development, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Reproduction LCC:Internal medicine |
| مصطلحات موضوعية: | 5-hydroxytryptamine (5-ht), hyperactivation, in vitro fertilization (ivf), spermatozoa, Reproduction, QH471-489, Internal medicine, RC31-1245 |
| الوصف: | In this study, we examined the effects of 5-hydroxytryptamine (5-HT) on the motility and hyperactivation of mouse spermatozoa. In addition, we examined whether 5-HT increases the success of in vitro fertilization (IVF) in mice. Interestingly, 5-HT and agonists of the 5-HT2, 5-HT3, 5-HT4, and 5-HT7 receptors significantly increased the percentage of hyperactivated spermatozoa but did not affect the percentage of motile spermatozoa. Moreover, agonists of the 5-HT2, 5-HT3, and 5-HT4 receptors significantly affected the velocities, linearity, straightness, wobbler coefficient, amplitude and/or frequency of spermatozoa. In particular, the improvement of hyperactivation by 5-HT was strongly inhibited by antagonists of the receptors 5-HT4 and 5-HT7 and was completely inhibited by a mixture of the four 5-HT-receptor antagonists. The increase in hyperactivation by the agonists was significantly inhibited by the corresponding 5-HT-receptor antagonist. Moreover, 5-HT significantly increased the percentage of two-cell embryos. The increase in the IVF success rate by 5-HT was significantly inhibited by a 5-HT4-receptor antagonist. These results suggest that 5-HT increased hyperactivation through the 5-HT receptors and increased the success of IVF in mice. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0916-8818 1348-4400 |
| Relation: | https://www.jstage.jst.go.jp/article/jrd/65/6/65_2019-082/_pdf/-char/en; https://doaj.org/toc/0916-8818; https://doaj.org/toc/1348-4400 |
| DOI: | 10.1262/jrd.2019-082 |
| URL الوصول: | https://doaj.org/article/f6434df677194044a9ddb7af87707a40 |
| رقم الأكسشن: | edsdoj.f6434df677194044a9ddb7af87707a40 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 09168818 13484400 |
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| DOI: | 10.1262/jrd.2019-082 |