دورية أكاديمية
Activation of FoxO1/SIRT1/RANKL/OPG pathway may underlie the therapeutic effects of resveratrol on aging-dependent male osteoporosis
العنوان: | Activation of FoxO1/SIRT1/RANKL/OPG pathway may underlie the therapeutic effects of resveratrol on aging-dependent male osteoporosis |
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المؤلفون: | Omnia Ameen, Rania I. Yassien, Yahya M. Naguib |
المصدر: | BMC Musculoskeletal Disorders, Vol 21, Iss 1, Pp 1-14 (2020) |
بيانات النشر: | BMC, 2020. |
سنة النشر: | 2020 |
المجموعة: | LCC:Diseases of the musculoskeletal system |
مصطلحات موضوعية: | Male osteoporosois, Type II osteoporosis, Aging, Resveratrol, FoxO1, SIRT1, Diseases of the musculoskeletal system, RC925-935 |
الوصف: | Abstract Background Age-dependent male osteoporosis remains a poorly studied medical problem despite its significance. It is estimated that at least 1 of 5 men will suffer from osteoporotic consequences. Given that multiple mechanisms are involved in the process of senescence, much attention has been given to compounds with polymodal actions. To challenge such a health problem, we tested here the therapeutic potential of resveratrol in male osteoporosis. We also studied the possible molecular mechanisms that may underlie resveratrol effects. Methods Thirty male Wistar albino rats were used in the present study. Rats were divided (10/group) into: control (3–4 months old weighing 150–200 g receiving vehicle), aged (18–20 months old, weighing 350–400 g and receiving vehicle), and resveratrol treated aged (18–20 months old, weighing 350–400 g and receiving resveratrol 20 mg/kg/day for 6 weeks) groups. Assessment of serum calcium, phosphate, bone specific alkaline phosphatase, inflammatory cytokines, oxidative stress markers, and rat femur gene expression of FoxO1, SIRT1, RANKL and OPG proteins was carried out. Histopathological assessment of different levels of rat femur was also performed. Results Age-dependent osteoporosis resulted in significant increase in serum levels of phosphate, bone specific alkaline phosphatase, hsCRP, IL-1β, IL-6, TNF-α, MDA, NO, and RANKL gene expression. However, there was significant decrease in serum level of GSH, and gene expression of FoxO1, SIRT1 and OPG. Osteoporotic changes were seen in femur epiphysis, metaphysis and diaphysis. Resveratrol restored significantly age-dependent osteoporotic changes. Conclusion We concluded that resveratrol can play an important role in the prevention of male osteoporosis. Resveratrol can counter the molecular changes in male osteoporosis via anti-inflammatory, anti-oxidant and gene modifying effects. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 1471-2474 27641368 |
Relation: | http://link.springer.com/article/10.1186/s12891-020-03389-w; https://doaj.org/toc/1471-2474 |
DOI: | 10.1186/s12891-020-03389-w |
URL الوصول: | https://doaj.org/article/f67c6365b276413689d9f5a86004ad7f |
رقم الأكسشن: | edsdoj.f67c6365b276413689d9f5a86004ad7f |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 14712474 27641368 |
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DOI: | 10.1186/s12891-020-03389-w |