دورية أكاديمية
miR-128-3p is involved in aluminum-induced cognitive impairment by regulating the Sirt1-Keap1/Nrf2 pathway
| العنوان: | miR-128-3p is involved in aluminum-induced cognitive impairment by regulating the Sirt1-Keap1/Nrf2 pathway |
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| المؤلفون: | Huan Li, Yan Liu, Xiangmeng Wang, Chaoqun Xu, Xiaoyu Zhang, Jing Zhang, Li Lin, Qiao Niu |
| المصدر: | Ecotoxicology and Environmental Safety, Vol 271, Iss , Pp 115966- (2024) |
| بيانات النشر: | Elsevier, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Environmental pollution LCC:Environmental sciences |
| مصطلحات موضوعية: | MiR-128–3p, Oxidative stress, Neuronal apoptosis, Cognitive impairment, Environmental pollution, TD172-193.5, Environmental sciences, GE1-350 |
| الوصف: | Aluminum (Al) is a common neurotoxicant in the environment, but the molecular mechanism of its toxic effects is still unclear. Studies have shown that aluminum exposure causes an increase in neuronal apoptosis. The aim of this study was to investigate the mechanism and signaling pathway of neuronal apoptosis induced by aluminum exposure. The rat model was established by intraperitoneal injection of maltol aluminum for 90 days. The results showed that the escape latency of the three groups exposed to maltol aluminum was higher than that of the control group on the 3rd, 4th and 5th days of the positioning cruise experiment (P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0147-6513 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S0147651324000411; https://doaj.org/toc/0147-6513 |
| DOI: | 10.1016/j.ecoenv.2024.115966 |
| URL الوصول: | https://doaj.org/article/eef75389f26d47f4a73cd6f1da0ed193 |
| رقم الأكسشن: | edsdoj.f75389f26d47f4a73cd6f1da0ed193 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 01476513 |
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| DOI: | 10.1016/j.ecoenv.2024.115966 |