دورية أكاديمية
The impact of synbiotic on serum sCD163/sTWEAK, paraoxonase 1, and lipoproteins in patients with chronic heart failure: a randomized, triple-blind, controlled trial
العنوان: | The impact of synbiotic on serum sCD163/sTWEAK, paraoxonase 1, and lipoproteins in patients with chronic heart failure: a randomized, triple-blind, controlled trial |
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المؤلفون: | Shakiba Shoaei Matin, Farzad Shidfar, Nasim Naderi, Ahmad Amin, Fatemeh Sadat Hosseini-Baharanchi, Afsaneh dehnad |
المصدر: | Scientific Reports, Vol 14, Iss 1, Pp 1-8 (2024) |
بيانات النشر: | Nature Portfolio, 2024. |
سنة النشر: | 2024 |
المجموعة: | LCC:Medicine LCC:Science |
مصطلحات موضوعية: | Synbiotic, Heart failure, Lipid profile, Paraoxonase, sCD163/sTWEAK, Cholesterol, Medicine, Science |
الوصف: | Abstract Cardiovascular disease is one of the leading causes of death worldwide. Evidence suggests that alterations in the gut microbiome could play a role in cardiovascular diseases, including heart failure. The purpose of this study was to evaluate the effect of synbiotics on serum paraoxonase 1(PON1), soluble CD163/soluble TNF-like weak inducer of apoptosis (sCD163/sTWEAK), and lipid profile, which are involved in heart failure in patients with chronic heart failure. In this triple-blind randomized clinical trial, 90 eligible patients were included in the study. They were randomly assigned to receive one capsule (500 mg) of synbiotics or a placebo daily for ten weeks. Serum PON1, sCD163/sTWEAK, and lipid profiles were measured at the beginning and end of the study. The data were analyzed by SPSS 24, and the p-value |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 2045-2322 |
Relation: | https://doaj.org/toc/2045-2322 |
DOI: | 10.1038/s41598-024-69560-8 |
URL الوصول: | https://doaj.org/article/f77a89f373664b7f82eaa3e8dfe210e2 |
رقم الأكسشن: | edsdoj.f77a89f373664b7f82eaa3e8dfe210e2 |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 20452322 |
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DOI: | 10.1038/s41598-024-69560-8 |