دورية أكاديمية
Circulating adrenal and gonadal steroid hormones heterogeneity in active young males and the contribution of 11-oxy androgens
| العنوان: | Circulating adrenal and gonadal steroid hormones heterogeneity in active young males and the contribution of 11-oxy androgens |
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| المؤلفون: | Amanda C. Swart, Desmaré van Rooyen, Therina du Toit, Bianca Heyns, John Molphy, Mathew Wilson, Roisin Leahy, Stephen L. Atkin |
| المصدر: | Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024) |
| بيانات النشر: | Nature Portfolio, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Androgen replacement therapy, Hypogonadism, 11β-hydroxyandrostenedione (11OHA4 11OHAD11OHAn), 11-ketotestosterone (11KT), Dehydroepiandrosterone (DHEA), Cytochrome P450 11β hydroxylase (CYP11B1), Medicine, Science |
| الوصف: | Abstract The classical androgens, testosterone and dihydrotestosterone, together with dehydroepiandrosterone, the precusrsor to all androgens, are generally included in diagnostic steroid evaluations of androgen excess and deficiency disorders and monitored in androgen replacement and androgen suppressive therapies. The C11-oxy androgens also contribute to androgen excess disorders and are still often excluded from clinical and research-based steroids analysis. The contribution of the C11-oxy androgens to the androgen pool has not been considered in androgen deficiency. An exploratory investigation into circulating adrenal and gonadal steroid hormones in men was undertaken as neither the classical androgens nor the C11-oxy androgens have been evaluated in the context of concurrent measurement of all adrenal steroid hormones. Serum androgens, mineralocorticoids, glucocorticoids, progesterones and androgens were assessed in 70 healthy young men using ultra high performance supercritical fluid chromatography and tandem mass spectrometry. Testosterone, 24.5 nmol/L was the most prominent androgen detected in all participants while dihydrotestosterone, 1.23 nmol/L, was only detected in 25% of the participants. The 11-oxy androgens were present in most of the participants with 11-hydroxyandrostenedione, 3.37 nmol, in 98.5%, 11-ketoandrostenedione 0.764 in 77%, 11-hydroxytestosterone, 0.567 in 96% and 11-ketotestosterone: 0.440 in 63%. A third of the participants with normal testosterone and comparable 11-ketotestosterone, had significantly lower dehydroepiandrosterone (p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2045-2322 |
| Relation: | https://doaj.org/toc/2045-2322 |
| DOI: | 10.1038/s41598-024-66749-9 |
| URL الوصول: | https://doaj.org/article/f78d9d9430704a56a2d917a282ce7e94 |
| رقم الأكسشن: | edsdoj.f78d9d9430704a56a2d917a282ce7e94 |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 20452322 |
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| DOI: | 10.1038/s41598-024-66749-9 |