BackgroundCancer caregivers directly affect patient health outcomes. To maintain the function and health of caregivers so that patients can receive efficient care, we must pay more attention to caregivers’ quality of life in the process of caring for patients. However, the factors influencing caregivers’ quality of life are complex.AimTo assess caregivers’ quality of life in the process of caring for cancer patients and to explore the factors associated with it.DesignThis was a descriptive correlational study. A self-report questionnaire was used to anonymously collect data from one Chinese cancer hospital. The Functional Assessment of Chronic Illness Therapy-Spiritual Well-Being (FACIT-Sp-12), General Self-efficacy Scale (GSES), Positive and Negative Affect Schedule (PANAS), Connor-Davidson Resilience Scale 10 (CD-RISC-10), 24-item Caregiver Burden Inventory (CBI) and Caregiver Evaluation Questionnaire were used to measure caregivers’ spiritual well-being, self-efficacy, affective well-being, resilience, caregiver burden and quality of life. One-way analysis of variance, the Kruskal–Wallis H test and multiple regression analysis were applied to measure the factors influencing caregivers’ situations.Setting and participantsA total of 315 caregivers of cancer patients were selected by convenience sampling. All participants were invited to complete the questionnaire through a one-on-one approach.ResultsThe mean score for caregiver quality of life was 204.62 ± 36.61. After controlling for demographic factors, self-efficacy (β’ = 0.265, p
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