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The Effects of TiO2 Nanoparticles on Cisplatin Cytotoxicity in Cancer Cell Lines

التفاصيل البيبلوغرافية
العنوان: The Effects of TiO2 Nanoparticles on Cisplatin Cytotoxicity in Cancer Cell Lines
المؤلفون: Basma Salama, El-Said El-Sherbini, Gehad El-Sayed, Mohamed El-Adl, Koki Kanehira, Akiyoshi Taniguchi
المصدر: International Journal of Molecular Sciences, Vol 21, Iss 2, p 605 (2020)
بيانات النشر: MDPI AG, 2020.
سنة النشر: 2020
المجموعة: LCC:Biology (General)
LCC:Chemistry
مصطلحات موضوعية: titanium dioxide nanoparticles, cisplatin, cytotoxicity, drug resistance, p-glycoprotein, Biology (General), QH301-705.5, Chemistry, QD1-999
الوصف: There have been many studies on improving the efficacy of cisplatin and on identifying safe compounds that can overcome multi-drug resistance (MDR) acquired by cancer cells. Our previous research showed that polyethylene glycol-modified titanium dioxide nanoparticles (TiO2 PEG NPs) affect cell membrane receptors, resulting in their aggregation, altered localization and downregulation. TiO2 PEG NPs may affect P-glycoprotein (P-gp), a membrane efflux channel involved in MDR. In this study, we investigated the effect of TiO2 PEG NPs on cisplatin cytotoxicity. We used HepG2 cells, which highly express P-gp and A431 cells, which show low expression of P-gp. The results showed that 10 µg/mL 100 nm TiO2 PEG NPs increased intracellular cisplatin levels and cytotoxicity in HepG2 cells but not in A431 cells. TiO2 PEG NPs treatment decreased the expression level of P-gp in HepG2 cells. Our findings indicate that TiO2 PEG NPs enhance cisplatin cytotoxicity by down regulating P-gp and that TiO2 PEG NPs are promising candidates for inhibiting P-gp and reversing drug resistance acquired by cancer cells.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1422-0067
Relation: https://www.mdpi.com/1422-0067/21/2/605; https://doaj.org/toc/1422-0067
DOI: 10.3390/ijms21020605
URL الوصول: https://doaj.org/article/cf7f0d7df4b64f7c883c18e74bec496b
رقم الأكسشن: edsdoj.f7f0d7df4b64f7c883c18e74bec496b
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:14220067
DOI:10.3390/ijms21020605