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Cross-serotype interactions and disease outcome prediction of dengue infections in Vietnam

التفاصيل البيبلوغرافية
العنوان: Cross-serotype interactions and disease outcome prediction of dengue infections in Vietnam
المؤلفون: R. Aguas, I. Dorigatti, L. Coudeville, C. Luxemburger, N. M. Ferguson
المصدر: Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
بيانات النشر: Nature Portfolio, 2019.
سنة النشر: 2019
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: Abstract Dengue pathogenesis is extremely complex. Dengue infections are thought to induce life-long immunity from homologous challenges as well as a multi-factorial heterologous risk enhancement. Here, we use the data collected from a prospective cohort study of dengue infections in schoolchildren in Vietnam to disentangle how serotype interactions modulate clinical disease risk in the year following serum collection. We use multinomial logistic regression to correlate the yearly neutralizing antibody measurements obtained with each infecting serotype in all dengue clinical cases collected over the course of 6 years (2004–2009). This allowed us to extrapolate a fully discretised matrix of serotype interactions, revealing clear signals of increased risk of clinical illness in individuals primed with a previous dengue infection. The sequences of infections which produced a higher risk of dengue fever upon secondary infection are: DEN1 followed by DEN2; DEN1 followed by DEN4; DEN2 followed by DEN3; and DEN4 followed by DEN3. We also used this longitudinal data to train a machine learning algorithm on antibody titre differences between consecutive years to unveil asymptomatic dengue infections and estimate asymptomatic infection to clinical case ratios over time, allowing for a better characterisation of the population’s past exposure to different serotypes.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2045-2322
Relation: https://doaj.org/toc/2045-2322
DOI: 10.1038/s41598-019-45816-6
URL الوصول: https://doaj.org/article/f80d98ce16244502b28f036b29239f13
رقم الأكسشن: edsdoj.f80d98ce16244502b28f036b29239f13
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20452322
DOI:10.1038/s41598-019-45816-6