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Microcluster colloidosomes for hemostat delivery into complex wounds: A platform inspired by the attack action of torpedoes

التفاصيل البيبلوغرافية
العنوان: Microcluster colloidosomes for hemostat delivery into complex wounds: A platform inspired by the attack action of torpedoes
المؤلفون: Bitao Lu, Enling Hu, Ruiqi Xie, Kun Yu, Fei Lu, Rong Bao, Chenhui Wang, Guangqian Lan, Fangyin Dai
المصدر: Bioactive Materials, Vol 16, Iss , Pp 372-387 (2022)
بيانات النشر: KeAi Communications Co., Ltd., 2022.
سنة النشر: 2022
المجموعة: LCC:Materials of engineering and construction. Mechanics of materials
LCC:Biology (General)
مصطلحات موضوعية: Torpedoes-inspired, Microcluster colloidosomes, Magnetic guidance, Disintegration, Hemostasis, Materials of engineering and construction. Mechanics of materials, TA401-492, Biology (General), QH301-705.5
الوصف: Complex yet lethal wounds with uncontrollable bleeding hinder conventional hemostats from clotting blood at the source or deep sites of injury vasculature, thereby causing massive blood loss and significantly increased mortality. Inspired by the attack action of torpedoes, we synthesized microcluster (MC) colloidosomes equipped with magnetic-mediated navigation and “blast” systems to deliver hemostats into the cavity of vase-type wounds. CaCO3/Fe2O3 (CF) microparticles functionalized with Arg-Gly-Asp (RGD) modified polyelectrolyte multilayers were co-assembled with oppositely charged zwitterionic carbon dots (CDs) to form MC colloidosomes, which were loaded with thrombin and protonated tranexamic acid (TXA-NH3+). The composite microparticles moved against blood flow under magnetic mediation and simultaneously disassembled for the burst release of thrombin stimulated by TXA-NH3+. The CO2 bubbles generated during disassembly produced a “blast” that propelled thrombin into the wound cavity. Severe bleeding in a vase-type hemorrhage model in the rabbit liver was rapidly controlled within ∼60 s. Furthermore, in vivo subcutaneous muscle and liver implantation models demonstrated excellent biodegradability of MC colloidosomes. This study is the first to propose a novel strategy based on the principle of torpedoes for transporting hemostats into vase-type wounds to achieve rapid hemostasis, creating a new paradigm for combating trauma treatment.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2452-199X
Relation: http://www.sciencedirect.com/science/article/pii/S2452199X22000020; https://doaj.org/toc/2452-199X
DOI: 10.1016/j.bioactmat.2022.01.002
URL الوصول: https://doaj.org/article/f838437083b34c7da950302b51aa895d
رقم الأكسشن: edsdoj.f838437083b34c7da950302b51aa895d
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:2452199X
DOI:10.1016/j.bioactmat.2022.01.002