دورية أكاديمية
Microcluster colloidosomes for hemostat delivery into complex wounds: A platform inspired by the attack action of torpedoes
العنوان: | Microcluster colloidosomes for hemostat delivery into complex wounds: A platform inspired by the attack action of torpedoes |
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المؤلفون: | Bitao Lu, Enling Hu, Ruiqi Xie, Kun Yu, Fei Lu, Rong Bao, Chenhui Wang, Guangqian Lan, Fangyin Dai |
المصدر: | Bioactive Materials, Vol 16, Iss , Pp 372-387 (2022) |
بيانات النشر: | KeAi Communications Co., Ltd., 2022. |
سنة النشر: | 2022 |
المجموعة: | LCC:Materials of engineering and construction. Mechanics of materials LCC:Biology (General) |
مصطلحات موضوعية: | Torpedoes-inspired, Microcluster colloidosomes, Magnetic guidance, Disintegration, Hemostasis, Materials of engineering and construction. Mechanics of materials, TA401-492, Biology (General), QH301-705.5 |
الوصف: | Complex yet lethal wounds with uncontrollable bleeding hinder conventional hemostats from clotting blood at the source or deep sites of injury vasculature, thereby causing massive blood loss and significantly increased mortality. Inspired by the attack action of torpedoes, we synthesized microcluster (MC) colloidosomes equipped with magnetic-mediated navigation and “blast” systems to deliver hemostats into the cavity of vase-type wounds. CaCO3/Fe2O3 (CF) microparticles functionalized with Arg-Gly-Asp (RGD) modified polyelectrolyte multilayers were co-assembled with oppositely charged zwitterionic carbon dots (CDs) to form MC colloidosomes, which were loaded with thrombin and protonated tranexamic acid (TXA-NH3+). The composite microparticles moved against blood flow under magnetic mediation and simultaneously disassembled for the burst release of thrombin stimulated by TXA-NH3+. The CO2 bubbles generated during disassembly produced a “blast” that propelled thrombin into the wound cavity. Severe bleeding in a vase-type hemorrhage model in the rabbit liver was rapidly controlled within ∼60 s. Furthermore, in vivo subcutaneous muscle and liver implantation models demonstrated excellent biodegradability of MC colloidosomes. This study is the first to propose a novel strategy based on the principle of torpedoes for transporting hemostats into vase-type wounds to achieve rapid hemostasis, creating a new paradigm for combating trauma treatment. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 2452-199X |
Relation: | http://www.sciencedirect.com/science/article/pii/S2452199X22000020; https://doaj.org/toc/2452-199X |
DOI: | 10.1016/j.bioactmat.2022.01.002 |
URL الوصول: | https://doaj.org/article/f838437083b34c7da950302b51aa895d |
رقم الأكسشن: | edsdoj.f838437083b34c7da950302b51aa895d |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 2452199X |
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DOI: | 10.1016/j.bioactmat.2022.01.002 |