دورية أكاديمية
The synergy of 177Lu-FAPI-46 with tyrosine kinase inhibitor in a sarcoma patient-derived xenograft mouse model
| العنوان: | The synergy of 177Lu-FAPI-46 with tyrosine kinase inhibitor in a sarcoma patient-derived xenograft mouse model |
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| المؤلفون: | Jing-Ren Tseng, Cheng-Lung Hsu, Hsin-Hua Hsieh, Kung-Chu Ho, Yi-Hsiu Chung, Chun-Yi Wu |
| المصدر: | Biomedical Journal, Vol 47, Iss 3, Pp 100744- (2024) |
| بيانات النشر: | Elsevier, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine (General) LCC:Biology (General) |
| مصطلحات موضوعية: | Sarcoma, Patient-derived xenograft (PDX), Fibroblast activation protein (FAP), 177Lu-FAPI-46, Medicine (General), R5-920, Biology (General), QH301-705.5 |
| الوصف: | Background: Given the heterogeneity and high mortality associated with metastatic soft tissue sarcoma, this study aims to evaluate the therapeutic efficacy of combining 177Lu-FAPI-46 with Pazopanib against this malignancy. Methods: Patient-derived xenograft (PDX)-bearing mice were randomly divided into three groups: the control group, the 177Lu-FAPI-46 monotherapy group, and the 177Lu-FAPI-46 combined with Pazopanib therapy group. Therapeutic efficacy was regularly monitored. Results: The microPET imaging showed a 0.84-fold decrease in the T/M ratio of 68Ga-FAPI-46 on day 7/8 post combination therapy, while the control group exhibited a 1.23-fold increase. Combination therapy significantly inhibited tumor proliferation, as evidenced by reduced Ki-67 and increased caspase 3 expressions. Notably, there was no significant body weight loss observed in any group. Conclusion: This study successfully demonstrated the reduction in FAP expression and suppression of tumor volume in sarcoma PDX following the combination therapy of 177Lu-FAPI-46 with Pazopanib. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2319-4170 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2319417024000477; https://doaj.org/toc/2319-4170 |
| DOI: | 10.1016/j.bj.2024.100744 |
| URL الوصول: | https://doaj.org/article/f83c372728994ea3895513cc77e1168e |
| رقم الأكسشن: | edsdoj.f83c372728994ea3895513cc77e1168e |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 23194170 |
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| DOI: | 10.1016/j.bj.2024.100744 |