دورية أكاديمية
FARSB Facilitates Hepatocellular Carcinoma Progression by Activating the mTORC1 Signaling Pathway
| العنوان: | FARSB Facilitates Hepatocellular Carcinoma Progression by Activating the mTORC1 Signaling Pathway |
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| المؤلفون: | Yaofeng Wang, Gengqiao Wang, Shaobo Hu, Chuanzheng Yin, Peng Zhao, Xing Zhou, Shuyu Shao, Ran Liu, Wenjun Hu, Gang Logan Liu, Wenbo Ke, Zifang Song |
| المصدر: | International Journal of Molecular Sciences, Vol 24, Iss 23, p 16709 (2023) |
| بيانات النشر: | MDPI AG, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | FARSB, hepatocellular carcinoma, mTORC1, Raptor, ferroptosis, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | Hepatocellular carcinoma (HCC) is a common malignant tumor with high mortality. Human phenylalanine tRNA synthetase (PheRS) comprises two α catalytic subunits encoded by the FARSA gene and two β regulatory subunits encoded by the FARSB gene. FARSB is a potential oncogene, but no experimental data show the relationship between FARSB and HCC progression. We found that the high expression of FARSB in liver cancer is closely related to patients’ low survival and poor prognosis. In liver cancer cells, the mRNA and protein expression levels of FARSB are increased and promote cell proliferation and migration. Mechanistically, FARSB activates the mTOR complex 1 (mTORC1) signaling pathway by binding to the component Raptor of the mTORC1 complex to play a role in promoting cancer. In addition, we found that FARSB can inhibit erastin-induced ferroptosis by regulating the mTOR signaling pathway, which may be another mechanism by which FARSB promotes HCC progression. In summary, FARSB promotes HCC progression and is associated with the poor prognosis of patients. FARSB is expected to be a biomarker for early screening and treatment of HCC. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| Relation: | https://www.mdpi.com/1422-0067/24/23/16709; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067 |
| DOI: | 10.3390/ijms242316709 |
| URL الوصول: | https://doaj.org/article/f899b5fda21e444f82d7f30839227652 |
| رقم الأكسشن: | edsdoj.f899b5fda21e444f82d7f30839227652 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 16616596 |
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| DOI: | 10.3390/ijms242316709 |