دورية أكاديمية
Immunohistomorphometric changes of the pituitary gonadotropic cells after testosterone application in a rat model of the andropause
| العنوان: | Immunohistomorphometric changes of the pituitary gonadotropic cells after testosterone application in a rat model of the andropause |
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| المؤلفون: | Nataša Ristić, Vladimir Ajdžanović, Dragana Petrović-Kosanović, Marko Miler, Gordana Ušćebrka, Verica Milošević |
| المصدر: | Macedonian Veterinary Review, Vol 42, Iss 1, Pp 5-13 (2019) |
| بيانات النشر: | Ss.Cyril and Methodius University, Skopje, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Veterinary medicine |
| مصطلحات موضوعية: | andropause, testosterone, gonadotropic cells, immunohistomorphometry, optical density, Veterinary medicine, SF600-1100 |
| الوصف: | Andropause, the culminating phase of male ageing, is characterized by deregulation of the hypothalamic-pituitarygonadal axis and low circulating free testosterone. The aim of this study was to investigate the immunohistomorphometric characteristics of the pituitary gonadotropic i.e. follicle-stimulating hormone (FSH) and the luteinizing hormone (LH) producing cells after testosterone application in a rat model of the andropause. Middle-aged Wistar rats were divided into orchidectomized (ORX; n=8) and testosterone treated orchidectomized (ORX+T; n=8) groups. Testosterone propionate (5 mg/kg b.m. /day) was administered for three weeks, while the ORX group received the vehicle alone. Immunohistochemically stained FSH and LH cells underwent morphometric and optical density-related analysis, while circulating concentrations of the sex steroids were measured by immunoassays. Serum concentrations of testosterone and estradiol were significantly (p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1409-7621 1857-7415 |
| Relation: | https://macvetrev.mk/LoadArticleContent?DOI=10.2478_macvetrev_2018_0023; https://doaj.org/toc/1409-7621; https://doaj.org/toc/1857-7415 |
| DOI: | 10.2478/macvetrev-2018-0023 |
| URL الوصول: | https://doaj.org/article/f8a01c5d375b44f2a7fab2ea6c5d7487 |
| رقم الأكسشن: | edsdoj.f8a01c5d375b44f2a7fab2ea6c5d7487 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14097621 18577415 |
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| DOI: | 10.2478/macvetrev-2018-0023 |