دورية أكاديمية
Corylus avellana L. modulates neurobehaviour and brain chemistry following high-fat diet
| العنوان: | Corylus avellana L. modulates neurobehaviour and brain chemistry following high-fat diet |
|---|---|
| المؤلفون: | Anthony T Olofinnade, Adejoke Y Onaolapo, Olakunle J Onaolapo, Olugenga A Olowe, Adriano Mollica, Gokhan Zengin, Azurra Stefanucci |
| المصدر: | Frontiers in Bioscience-Landmark, Vol 26, Iss 3, Pp 537-551 (2020) |
| بيانات النشر: | IMR Press, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Biochemistry LCC:Biology (General) |
| مصطلحات موضوعية: | antioxidant, brain, corylus avellana, functional food, nutraceutical, neurobehaviour, metabolic, Biochemistry, QD415-436, Biology (General), QH301-705.5 |
| الوصف: | Consumption of a high-fat diet has adverse impacts on metabolism, neurobehavioral, and neurochemical homeostasis in both humans and experimental animals. Here, we examined the effects of two different cultivars of Corylus avellana L. in a mouse model of metabolic syndrome. Corylus avellana L. reduced weight gain in mice that were treated with a high-fat diet, improved their behavioral parameters as exemplified by locomotion and rearing, working-memory, and reduced grooming and anxiety indices. Both Corylus avellana L. varieties reduced blood glucose levels and lipid peroxidation, improved lipid profile, and antioxidant status in mice placed on a high fat diet. Finally, brain acetylcholinesterase activity was also reduced, dopamine level was increased, while caspase-3 level was reduced. Thus, the Corylus avellana L. cultivars improve metabolic, behavioral, and neurochemical homeostasis in a diet with a high-fat content. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2768-6701 |
| Relation: | https://www.imrpress.com/journal/FBL/26/3/10.2741/4906; https://doaj.org/toc/2768-6701 |
| DOI: | 10.2741/4906 |
| URL الوصول: | https://doaj.org/article/addf8d45c95e479c9ea93a3a02c44a8c |
| رقم الأكسشن: | edsdoj.f8d45c95e479c9ea93a3a02c44a8c |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 27686701 |
|---|---|
| DOI: | 10.2741/4906 |